HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	12070169, 21118812, 10097102, 17620599
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 937
+	Rn
		663951 ARRB2_RAT (1-409): 0: 682: 95.85		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		827157 ARRB1_HUMAN (1-407): 0: 661: 76.15		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		685925 ARRB2_HUMAN (1-409): 0: 688: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		321494 ARRB2_HUMAN (1-409): 0: 688: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		321510 ARRB1_HUMAN (1-407): 0: 661: 76.15		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302104 ARRB2_HUMAN (1-409): 0: 688: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		119923 ARRB2_HUMAN (1-409): 0: 688: 100.00		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17
+	Hs
		685933 ARRB2_HUMAN (1-409): 0: 688: 100.00		AP3B2_HUMAN (16-594): 2.55e-174: 537: 28.71
+	Hs
		119935 ARRB1_HUMAN (1-407): 0: 661: 76.15		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17