Protein: KRA59
Keratin-associated protein 5-9 (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (Keratin-associated protein 5.9) (UHS keratin A) (UHS KerA) (Ultrahigh sulfur keratin-associated protein 5.9)

Gene: KRA59, KRTAP5-9
Organism: Homo sapiens
Interactions: 213
UniProt ID: P26371

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0008544 - epidermis development
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685889

RN111
E3 ubiquitin-protein ligase Arkadia

4

3

High-throughput

0.697

High

140147

SDCB1
Syntenin-1

3

5

High-throughput

0.675

High

225537

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

15

High-throughput

0.675

High

300110

GLRX3
Glutaredoxin-3

3

20

High-throughput

0.675

High

680774

PSA1
Proteasome subunit alpha type-1

3

4

High-throughput

0.675

High

685823

KR121
Keratin-associated protein 12-1

3

20

High-throughput

0.675

High

685824

KR122
Keratin-associated protein 12-2

3

20

High-throughput

0.675

High

685832

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.675

High

685833

KR109
Keratin-associated protein 10-9

3

20

High-throughput

0.675

High

685856

F161A
Protein FAM161A

3

4

High-throughput

0.675

High

685882

KRA56
Keratin-associated protein 5-6

3

20

High-throughput

0.675

High

685919

DOCK2
Dedicator of cytokinesis protein 2

3

16

High-throughput

0.675

High

685927

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

6

High-throughput

0.675

High

685933

KR412
Keratin-associated protein 4-12

3

20

High-throughput

0.675

High

685940

KRA92
Keratin-associated protein 9-2

3

20

High-throughput

0.675

High

685941

KR411
Keratin-associated protein 4-11

3

20

High-throughput

0.675

High

685944

KRA42
Keratin-associated protein 4-2

3

20

High-throughput

0.675

High

685964

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

3

18

High-throughput

0.675

High

685977

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

3

15

High-throughput

0.675

High

685971

CATZ
Cathepsin Z

5

4

High-throughput

0.657

High

685870

LCE1B
Late cornified envelope protein 1B

5

20

High-throughput

0.654

High

685955

NET4
Netrin-4

4

6

High-throughput

0.642

High

685831

KR107
Keratin-associated protein 10-7

2

20

High-throughput

0.633

High

685894

NUFP2
FMR1-interacting protein NUFIP2

2

20

High-throughput

0.633

High

685818

HXA1
Homeobox protein Hox-A1

3

20

High-throughput

0.619

High

685861

LCE3C
Late cornified envelope protein 3C

3

20

High-throughput

0.619

High

246217

MABP1
Mitogen-activated protein kinase-binding protein 1

3

12

High-throughput

0.616

High

303105

RGS20
Regulator of G-protein signaling 20

3

9

High-throughput

0.616

High

426051

PPB1
Alkaline phosphatase, placental type

3

9

High-throughput

0.616

High

685812

OTX1
Homeobox protein OTX1

3

20

High-throughput

0.616

High

685817

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

3

5

High-throughput

0.616

High

685820

MCSP
Sperm mitochondrial-associated cysteine-rich protein

3

20

High-throughput

0.616

High

685853

ZN124
Zinc finger protein 124

3

20

High-throughput

0.616

High

685855

KLH38
Kelch-like protein 38

3

10

High-throughput

0.616

High

685860

FA76B
Protein FAM76B

3

13

High-throughput

0.616

High

685862

LCE3E
Late cornified envelope protein 3E

3

20

High-throughput

0.616

High

685874

LCE4A
Late cornified envelope protein 4A

3

20

High-throughput

0.616

High

685875

LCE2A
Late cornified envelope protein 2A

3

20

High-throughput

0.616

High

685887

ATL4
ADAMTS-like protein 4

3

20

High-throughput

0.616

High

685907

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

3

13

High-throughput

0.616

High

685908

ZN439
Zinc finger protein 439

3

20

High-throughput

0.616

High

685909

CNNM3
Metal transporter CNNM3

3

12

High-throughput

0.616

High

685910

CTSR1
Cation channel sperm-associated protein 1

3

20

High-throughput

0.616

High

685912

ZN417
Zinc finger protein 417

3

20

High-throughput

0.616

High

685916

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

3

10

High-throughput

0.616

High

685921

PCSK5
Proprotein convertase subtilisin/kexin type 5

3

10

High-throughput

0.616

High

685930

ZN587
Zinc finger protein 587

3

20

High-throughput

0.616

High

685951

CHRD
Chordin

3

20

High-throughput

0.616

High

685961

NPDC1
Neural proliferation differentiation and control protein 1

3

16

High-throughput

0.616

High

685973

CRCT1
Cysteine-rich C-terminal protein 1

3

15

High-throughput

0.616

High

685975

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

3

10

High-throughput

0.616

High

685898

KR111
Keratin-associated protein 11-1

2

9

High-throughput

0.615

High

269904

SDC3
Syndecan-3

4

11

High-throughput

0.614

High

685839

TYRO3
Tyrosine-protein kinase receptor TYRO3

3

16

High-throughput

0.613

High

685829

KR105
Keratin-associated protein 10-5

2

20

High-throughput

0.611

High

685834

KR10B
Keratin-associated protein 10-11

2

20

High-throughput

0.611

High

159036

LCE2B
Late cornified envelope protein 2B

2

19

High-throughput

0.606

High

221319

SPY1
Protein sprouty homolog 1

2

20

High-throughput

0.606

High

303310

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

2

11

High-throughput

0.606

High

452170

PDIA1
Protein disulfide-isomerase

2

9

High-throughput

0.606

High

652278

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.606

High

685809

KRA59
Keratin-associated protein 5-9

2

20

High-throughput

0.606

High

685815

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

10

High-throughput

0.606

High

685825

KR10A
Keratin-associated protein 10-10

2

20

High-throughput

0.606

High

685826

KR123
Keratin-associated protein 12-3

2

20

High-throughput

0.606

High

685830

KR106
Keratin-associated protein 10-6

2

20

High-throughput

0.606

High

685845

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

7

High-throughput

0.606

High

685857

CRY2
Cryptochrome-2

2

8

High-throughput

0.606

High

685869

LCE1A
Late cornified envelope protein 1A

2

20

High-throughput

0.606

High

685881

KR511
Keratin-associated protein 5-11

2

20

High-throughput

0.606

High

685883

KRA54
Keratin-associated protein 5-4

2

20

High-throughput

0.606

High

685884

KRA53
Keratin-associated protein 5-3

2

20

High-throughput

0.606

High

685890

KRA52
Keratin-associated protein 5-2

2

12

High-throughput

0.606

High

685897

S13A5
Na(+)/citrate cotransporter

2

7

High-throughput

0.606

High

685899

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.606

High

685936

LCE3D
Late cornified envelope protein 3D

2

20

High-throughput

0.606

High

685937

KRA98
Keratin-associated protein 9-8

2

20

High-throughput

0.606

High

685939

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.606

High

685942

KRA45
Keratin-associated protein 4-5

2

20

High-throughput

0.606

High

685943

KRA44
Keratin-associated protein 4-4

2

20

High-throughput

0.606

High

685963

CNBP1
Beta-catenin-interacting protein 1

2

3

High-throughput

0.606

High

685837

CREB5
Cyclic AMP-responsive element-binding protein 5

3

20

High-throughput

0.604

High

3404

A0A0S2Z4U3
Syndecan

3

12

High-throughput

0.597

High

611704

BMP7
Bone morphogenetic protein 7

3

16

High-throughput

0.597

High

685972

DIC
Mitochondrial dicarboxylate carrier

2

9

High-throughput

0.590

High

685827

KR101
Keratin-associated protein 10-1

2

20

High-throughput

0.584

High

685819

FLT3L
Fms-related tyrosine kinase 3 ligand

2

0

High-throughput

0.580

High

685822

BPL1
Biotin--protein ligase

2

0

High-throughput

0.580

High

685821

MEOX2
Homeobox protein MOX-2

2

20

High-throughput

0.578

High

685893

NT2NA
Notch homolog 2 N-terminal-like protein A

2

20

High-throughput

0.578

High

221084

SPY2
Protein sprouty homolog 2

1

20

High-throughput

0.573

High

532376

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.573

High

599503

FAAA
Fumarylacetoacetase

1

1

High-throughput

0.573

High

608828

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

2

High-throughput

0.573

High

685850

JOS1
Josephin-1

1

8

High-throughput

0.573

High

685900

TB10C
Carabin

1

3

High-throughput

0.573

High

685938

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.573

High

685968

NLK
Serine/threonine-protein kinase NLK

1

3

High-throughput

0.573

High

685873

LCE3B
Late cornified envelope protein 3B

2

20

High-throughput

0.561

High

70121

CRTP1
Cysteine-rich tail protein 1

2

20

High-throughput

0.553

High

192358

GSC2
Homeobox protein goosecoid-2

2

20

High-throughput

0.553

High

209877

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

10

High-throughput

0.553

High

240181

KLK8
Kallikrein-8

2

6

High-throughput

0.553

High

354823

WNT11
Protein Wnt-11

2

9

High-throughput

0.553

High

449483

CRF
Corticoliberin

2

5

High-throughput

0.553

High

458183

ACHG
Acetylcholine receptor subunit gamma

2

8

High-throughput

0.553

High

665913

IBP6
Insulin-like growth factor-binding protein 6

2

10

High-throughput

0.553

High

685810

CO8A1
Collagen alpha-1(VIII) chain

2

8

High-throughput

0.553

High

685811

GRN
Progranulin

2

5

High-throughput

0.553

High

685814

GLP1R
Glucagon-like peptide 1 receptor

2

8

High-throughput

0.553

High

685838

HHEX
Hematopoietically-expressed homeobox protein HHEX

2

16

High-throughput

0.553

High

685842

PO4F2
POU domain, class 4, transcription factor 2

2

20

High-throughput

0.553

High

685843

SEM3B
Semaphorin-3B

2

6

High-throughput

0.553

High

685847

MOBP
Myelin-associated oligodendrocyte basic protein

2

9

High-throughput

0.553

High

685851

P2RY6
P2Y purinoceptor 6

2

7

High-throughput

0.553

High

685854

VWC2
Brorin

2

20

High-throughput

0.553

High

685864

KPRP
Keratinocyte proline-rich protein

2

7

High-throughput

0.553

High

685865

LCE1C
Late cornified envelope protein 1C

2

20

High-throughput

0.553

High

685866

LCE1D
Late cornified envelope protein 1D

2

20

High-throughput

0.553

High

685867

LCE1E
Late cornified envelope protein 1E

2

20

High-throughput

0.553

High

685868

LCE1F
Late cornified envelope protein 1F

2

20

High-throughput

0.553

High

685871

LELP1
Late cornified envelope-like proline-rich protein 1

2

6

High-throughput

0.553

High

685872

LCE3A
Late cornified envelope protein 3A

2

20

High-throughput

0.553

High

685876

LCE2C
Late cornified envelope protein 2C

2

20

High-throughput

0.553

High

685877

LCE2D
Late cornified envelope protein 2D

2

20

High-throughput

0.553

High

685878

LCE5A
Late cornified envelope protein 5A

2

20

High-throughput

0.553

High

685888

ATL5
ADAMTS-like protein 5

2

20

High-throughput

0.553

High

685895

GGN
Gametogenetin

2

2

High-throughput

0.553

High

685903

S15A3
Solute carrier family 15 member 3

2

5

High-throughput

0.553

High

685904

ZN440
Zinc finger protein 440

2

20

High-throughput

0.553

High

685906

ZN655
Zinc finger protein 655

2

17

High-throughput

0.553

High

685913

LNX1
E3 ubiquitin-protein ligase LNX

2

9

High-throughput

0.553

High

685918

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

12

High-throughput

0.553

High

685922

NKD1
Protein naked cuticle homolog 1

2

7

High-throughput

0.553

High

685924

ZN837
Zinc finger protein 837

2

20

High-throughput

0.553

High

685925

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

2

10

High-throughput

0.553

High

685928

ZN414
Zinc finger protein 414

2

6

High-throughput

0.553

High

685934

SCNM1
Sodium channel modifier 1

2

6

High-throughput

0.553

High

685948

ENKD1
Enkurin domain-containing protein 1

2

4

High-throughput

0.553

High

685950

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

7

High-throughput

0.553

High

685953

ZN696
Zinc finger protein 696

2

20

High-throughput

0.553

High

685954

ZN408
Zinc finger protein 408

2

20

High-throughput

0.553

High

685956

PGAP6
Post-GPI attachment to proteins factor 6

2

6

High-throughput

0.553

High

685958

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

2

High-throughput

0.553

High

685960

NECT3
Nectin-3

2

20

High-throughput

0.553

High

685969

UXT
Protein UXT

2

4

High-throughput

0.553

High

685970

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

2

4

High-throughput

0.553

High

685974

DCDC2
Doublecortin domain-containing protein 2

2

2

High-throughput

0.553

High

685978

RASD1
Dexamethasone-induced Ras-related protein 1

2

4

High-throughput

0.553

High

642195

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.549

High

685949

CXL16
C-X-C motif chemokine 16

2

5

High-throughput

0.533

High

50088

S22AN
Solute carrier family 22 member 23

1

3

High-throughput

0.523

High

208793

ZBT24
Zinc finger and BTB domain-containing protein 24

1

20

High-throughput

0.523

High

260835

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.523

High

604787

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.523

High

628573

ISK2
Serine protease inhibitor Kazal-type 2

1

1

High-throughput

0.523

High

685813

HPCL1
Hippocalcin-like protein 1

1

9

High-throughput

0.523

High

685816

NPBW2
Neuropeptides B/W receptor type 2

1

5

High-throughput

0.523

High

685835

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

High-throughput

0.523

High

685848

ZN266
Zinc finger protein 266

1

17

High-throughput

0.523

High

685852

TCEA2
Transcription elongation factor A protein 2

1

11

High-throughput

0.523

High

685863

CJ062
Uncharacterized protein C10orf62

1

5

High-throughput

0.523

High

685885

CK087
Uncharacterized protein C11orf87

1

5

High-throughput

0.523

High

685892

ATG9A
Autophagy-related protein 9A

1

5

High-throughput

0.523

High

685901

NNRD
ATP-dependent

1

6

High-throughput

0.523

High

685915

SCRB1
Scavenger receptor class B member 1

1

1

High-throughput

0.523

High

685920

NECT2
Nectin-2

1

20

High-throughput

0.523

High

685929

DHRS1
Dehydrogenase/reductase SDR family member 1

1

12

High-throughput

0.523

High

685931

P2RX4
P2X purinoceptor 4

1

3

High-throughput

0.523

High

685932

ZFY21
Zinc finger FYVE domain-containing protein 21

1

4

High-throughput

0.523

High

685935

BEX2
Protein BEX2

1

4

High-throughput

0.523

High

685946

YIPF3
Protein YIPF3

1

7

High-throughput

0.523

High

685952

F124B
Protein FAM124B

1

5

High-throughput

0.523

High

685959

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

9

High-throughput

0.523

High

685966

ZN581
Zinc finger protein 581

1

20

High-throughput

0.523

High

685967

NTRI
Neurotrimin

1

5

High-throughput

0.523

High

685945

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.515

High

333806

6PGL
6-phosphogluconolactonase

1

4

High-throughput

0.481

High

505303

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.481

High

685828

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.481

High

685836

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

685840

KRA11
Keratin-associated protein 1-1

1

20

High-throughput

0.481

High

685844

PTK7
Inactive tyrosine-protein kinase 7

1

13

High-throughput

0.481

High

685914

TBC16
TBC1 domain family member 16

1

5

High-throughput

0.481

High

685917

PHLA1
Pleckstrin homology-like domain family A member 1

1

20

High-throughput

0.481

High

685879

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

49152

POTB3
POTE ankyrin domain family member B3

1

6

High-throughput

0.470

High

59944

A2BDE7
PHLDA1 protein

1

20

High-throughput

0.470

High

63638

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

69631

A8K571
Bone morphogenetic protein 7

1

16

High-throughput

0.470

High

516968

NT2NC
Notch homolog 2 N-terminal-like protein C

1

20

High-throughput

0.470

High

685858

Q549C5
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.470

High

685859

YV018
Putative uncharacterized protein DKFZp434K191

1

5

High-throughput

0.470

High

685880

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.470

High

685891

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

685965

Q9NWL9
cDNA FLJ20748 fis, clone HEP05772

1

4

High-throughput

0.470

High

685976

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

4

High-throughput

0.464

High

483

NBPFJ
NBPF family member NBPF19

1

16

High-throughput

0.439

High

685841

BRME1
Break repair meiotic recombinase recruitment factor 1

1

4

High-throughput

0.439

High

685849

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.439

High

685902

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.439

High

685911

SPTA3
Spermatogenesis-associated protein 3

1

11

High-throughput

0.439

High

685957

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

7

High-throughput

0.439

High

685962

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.439

High

685896

Q86VL0
TCEA2 protein

1

11

High-throughput

0.417

High

685846

DNSL3
Deoxyribonuclease gamma

2

0

High-throughput

0.316

High

685886

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

2

0

High-throughput

0.316

High

685905

MT1M
Metallothionein-1M

2

0

High-throughput

0.316

High

316654

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.299

High

685923

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.299

High

685926

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.265

Low

685947

SPC1L
Speriolin-like protein

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025