HitPredict

Interactor 1: PSA5 (P32379)
Proteasome subunit alpha type-5 (Macropain subunit PUP2) (Multicatalytic endopeptidase complex subunit PUP2) (Proteasome component PUP2) (Proteinase YSCE subunit PUP2)
Gene: PUP2

Interactor 2: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	18511945, 37968396
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 260 Sc			1 945
+	Hs
		656297 PSA5_HUMAN (1-243): 1.39e-101: 297: 60.08		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		156342 PSA7_HUMAN (7-241): 1.16e-92: 275: 34.18		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		893734 PSA6_HUMAN (4-247): 3.94e-92: 273: 25.81		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		637529 PSA1_HUMAN (3-259): 2.18e-91: 272: 30.37		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		689 PSA5_HUMAN (1-243): 1.39e-101: 297: 60.08		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Dm
		1278636 PSA5_DROME (1-244): 4.44e-103: 301: 55.92		PSMD1_DROME (1-927): 0: 990: 36.04
+	Hs
		699 PSA6_HUMAN (4-247): 3.94e-92: 273: 25.81		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Hs
		685 PSA1_HUMAN (3-259): 2.18e-91: 272: 30.37		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Sp
		251850 PSA4_SCHPO (6-251): 5.7e-40: 140: 33.20		RPN2_SCHPO (3-938): 0: 1002: 41.56
+	Dm
		611652 PSA71_DROME (6-234): 7.92e-40: 140: 34.50		PSMD1_DROME (1-927): 0: 990: 36.04
+	Hs
		656214 PSA5_HUMAN (1-243): 1.39e-101: 297: 60.08		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		156281 PSA7_HUMAN (7-241): 1.16e-92: 275: 34.18		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		893662 PSA6_HUMAN (4-247): 3.94e-92: 273: 25.81		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		637407 PSA1_HUMAN (3-259): 2.18e-91: 272: 30.37		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Dm
		1278652 PSA5_DROME (1-244): 4.44e-103: 301: 55.92		Q9VW54_DROME (13-770): 0: 651: 17.61
+	Sp
		953217 PSA5_SCHPO (1-246): 1.34e-105: 307: 66.67		RPN1_SCHPO (9-770): 0: 621: 18.33
+	Dm
		611672 PSA71_DROME (6-234): 7.92e-40: 140: 34.50		Q9VW54_DROME (13-770): 0: 651: 17.61
+	Sp
		953201 PSA3_SCHPO (3-247): 1.84e-43: 149: 36.11		RPN1_SCHPO (9-770): 0: 621: 18.33
+	Sp
		953206 PSA4_SCHPO (6-251): 5.7e-40: 140: 33.20		RPN1_SCHPO (9-770): 0: 621: 18.33
+	Sc
		689178 PSA5_YEAST (1-260): 4.63e-106: 309: 100.00		RPN1_YEAST (9-573): 1.13e-134: 430: 17.33