HitPredict

Interactor 1: ARP2 (P32381)
Actin-related protein 2 (Actin-like protein ARP2) (Actin-like protein 2)
Gene: ARP2

Interactor 2: MYO5 (Q04439)
Myosin-5 (Actin-dependent myosin-I MYO5) (Class I unconventional myosin MYO5) (Type I myosin MYO5)
Gene: MYO5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	10648569, 18467557, 12429847, 38367669
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Actin~Myosin_head
Common GO terms	GO:0005524 - ATP binding GO:0015629 - actin cytoskeleton GO:0030479 - actin cortical patch GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Sc			1 1219
+	Sc
		689328 ARP2_YEAST (1-391): 0: 805: 100.00		MYO3_YEAST (1-1205): 0: 1087: 72.08
+	Sc
		887671 ACT_YEAST (1-389): 0: 557: 44.87		MYO5_YEAST (1-1219): 0: 1126: 100.00
+	Sp
		1358186 ARP2_SCHPO (6-391): 0: 590: 72.80		MYO1_SCHPO (1-1219): 0: 1043: 51.57
+	Hs
		724738 ACTB_HUMAN (2-389): 0: 566: 46.39		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Hs
		724762 ACTG_HUMAN (2-389): 0: 566: 46.13		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Mm
		892205 ACTB_MOUSE (2-389): 0: 566: 46.39		MYH9_MOUSE (7-1102): 0: 1015: 23.46
+	Rn
		892228 ACTB_RAT (2-389): 0: 566: 46.39		MYH9_RAT (7-1122): 0: 1013: 23.70
+	Hs
		724766 ACTC_HUMAN (2-389): 0: 559: 45.88		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Hs
		724767 ACTS_HUMAN (2-389): 0: 559: 45.62		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Rn
		892236 ACTB_RAT (2-389): 0: 566: 46.39		MYH10_RAT (2-1099): 0: 1010: 23.81
+	Hs
		725136 ACTC_HUMAN (2-389): 0: 559: 45.88		MYH10_HUMAN (2-1099): 0: 1013: 24.07
+	Hs
		725135 ACTH_HUMAN (2-389): 0: 556: 45.36		MYH10_HUMAN (2-1099): 0: 1013: 24.07
+	Hs
		724743 ARP2_HUMAN (7-389): 0: 549: 67.89		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Hs
		117656 ACTG_HUMAN (2-389): 0: 566: 46.13		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		117657 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		117658 ACTS_HUMAN (2-389): 0: 559: 45.62		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		214544 ACTB_HUMAN (2-389): 0: 566: 46.39		MYO1B_HUMAN (36-730): 5.19e-171: 538: 39.72
+	Hs
		214550 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1B_HUMAN (36-730): 5.19e-171: 538: 39.72
+	Hs
		297329 ACTB_HUMAN (2-389): 0: 566: 46.39		MYO1D_HUMAN (35-766): 3.11e-167: 524: 39.69
+	Hs
		297336 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1D_HUMAN (35-766): 3.11e-167: 524: 39.69