HitPredict

Interactor 1: A9UF07 (A9UF07)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Gene: BCR/ABL

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	1.00	0.625

Property	Details
Experiments	19380743
Identification Methods	tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1790 Hs			1 304
+	Hs
		69206 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		337388 ABL1_HUMAN (688-1790): 0: 938: 100.00		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		337389 ABL1_HUMAN (688-1790): 0: 938: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		337333 ABL1_HUMAN (688-1790): 0: 938: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Mm
		337631 ABL1_MOUSE (688-1790): 0: 857: 86.45		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		275157 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		337341 ABL1_HUMAN (688-1790): 0: 938: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Mm
		337621 ABL1_MOUSE (688-1790): 0: 857: 86.45		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		337418 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		337466 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67
+	Hs
		337608 ABL1_HUMAN (688-1790): 0: 938: 100.00		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		337337 ABL1_HUMAN (688-1790): 0: 938: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		337526 ABL1_HUMAN (688-1790): 0: 938: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		789043 ABL2_HUMAN (670-1790): 0: 727: 52.11		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		337637 ABL1_MOUSE (688-1790): 0: 857: 86.45		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00
+	Hs
		789044 ABL2_HUMAN (670-1790): 0: 727: 52.11		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		580953 ABL2_HUMAN (670-1790): 0: 727: 52.11		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		789054 ABL2_HUMAN (670-1790): 0: 727: 52.11		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209001 ABL2_HUMAN (670-1790): 0: 727: 52.11		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557630 ABL2_HUMAN (670-1790): 0: 727: 52.11		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00