Protein: ECR
Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1)

Gene: ECR
Organism: Drosophila melanogaster
Interactions: 107
UniProt ID: P34021

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628529

USP
Protein ultraspiracle

16

20

Small-scale

0.982

High

756442

FKB39
39 kDa FK506-binding nuclear protein

1

6

Small-scale

0.713

High

756472

CSN2
COP9 signalosome complex subunit 2

3

8

Small-scale

0.655

High

756509

Q9VYW2
FI10506p

2

20

Small-scale

0.640

High

756460

RIG
Gem-associated protein 5

2

3

Small-scale

0.624

High

756468

TRR
Histone-lysine N-methyltransferase trr

2

20

Small-scale

0.624

High

594740

7UP1
Steroid receptor seven-up, isoforms B/C

1

20

Small-scale

0.621

High

756437

ECR
Ecdysone receptor

1

19

Small-scale

0.621

High

756441

HR38
Probable nuclear hormone receptor HR38

1

19

Small-scale

0.621

High

756470

Q8WS79
Estrogen-related receptor splice variant

1

19

Small-scale

0.618

High

356723

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

2

20

Small-scale

0.601

High

756473

ARI1
E3 ubiquitin-protein ligase ariadne-1

1

6

Small-scale

0.573

High

756467

Q8IRB4
Diabetes and obesity regulated, isoform C

2

0

Small-scale

0.559

High

756481

Q9NIR3
CRC-B

1

11

Small-scale

0.552

High

756505

CDK8
Cyclin-dependent kinase 8

1

17

Small-scale

0.552

High

756510

MED14
Mediator of RNA polymerase II transcription subunit 14

1

20

Small-scale

0.552

High

756447

TRF
TBP-related factor

1

6

High-throughput

0.541

High

756471

NFKB1
Nuclear factor NF-kappa-B p110 subunit

1

20

High-throughput

0.541

High

674008

BRM
ATP-dependent helicase brm

1

20

Small-scale

0.515

High

756446

CP190
Centrosome-associated zinc finger protein Cp190

1

12

Small-scale

0.515

High

756461

NELFA
Negative elongation factor A

1

18

Small-scale

0.515

High

756464

OSA
Trithorax group protein osa

1

20

Small-scale

0.515

High

756484

SPT5H
Transcription elongation factor SPT5

1

19

Small-scale

0.515

High

756489

Q9VF03
Brahma associated protein 155 kDa

1

20

Small-scale

0.515

High

304836

E2F2
Transcription factor E2F2

1

5

High-throughput

0.508

High

356639

PLK4
Serine/threonine-protein kinase PLK4

1

8

High-throughput

0.508

High

660425

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.508

High

756439

CDK5
Cyclin-dependent kinase 5 homolog

1

10

High-throughput

0.508

High

756452

Q7K306
cyclin-dependent kinase

1

8

High-throughput

0.508

High

756454

Q7KPG8
CDK-activating kinase assembly factor MAT1

1

1

High-throughput

0.508

High

756465

AKT1
RAC serine/threonine-protein kinase

1

17

High-throughput

0.508

High

756476

CYCG
Cyclin G

1

1

High-throughput

0.508

High

756477

Q961D1
Cyclin-K

1

17

High-throughput

0.508

High

756486

Q9V9R2
Cullin-2

1

11

High-throughput

0.508

High

756488

Q9VDE3
LD08669p

1

20

High-throughput

0.508

High

756494

PAK
Serine/threonine-protein kinase Pak

1

10

High-throughput

0.508

High

756512

Q9W1J7
SKP1 component POZ domain-containing protein

1

2

High-throughput

0.508

High

120749

M9PE30
Transgelin

1

8

Small-scale

0.504

High

756444

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.501

High

756514

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.494

High

756445

Q24294
Dcdrk kinase

1

16

High-throughput

0.494

High

756459

Q86BS3
Chromator, isoform A

1

0

Small-scale

0.493

High

575838

CCNA
G2/mitotic-specific cyclin-A

1

0

High-throughput

0.486

High

303991

O76513
Cyclin-H

1

19

High-throughput

0.481

High

615050

PTC
Protein patched

1

1

High-throughput

0.481

High

756449

Q5U0V6
Cell division cycle 14, isoform B

1

7

High-throughput

0.481

High

756450

Q7JNL9
Dacapo

1

1

High-throughput

0.481

High

756453

Q7K3Q3
Regulatory protein zeste

1

3

High-throughput

0.481

High

756456

Q7KUZ5
Cyclin D, isoform D

1

8

High-throughput

0.481

High

756492

Q9VHB7
LD22928p

1

5

High-throughput

0.481

High

756504

Q9VSE6
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.481

High

54508

TPR
Nucleoprotein TPR

1

18

Small-scale

0.479

High

72168

A8WHL4
Bonus, isoform B

1

20

Small-scale

0.479

High

120167

M9PCJ7
Utx histone demethylase, isoform E

1

14

Small-scale

0.479

High

121922

M9PGZ8
Smrter, isoform G

1

20

Small-scale

0.479

High

121976

M9PH39
histone acetyltransferase

1

20

Small-scale

0.479

High

538226

HSP7D
Heat shock 70 kDa protein cognate 4

1

19

Small-scale

0.479

High

668150

CCNC
Cyclin-C

1

18

Small-scale

0.479

High

756448

YAP1
Transcriptional coactivator yorkie

1

13

Small-scale

0.479

High

756455

MED13
Mediator of RNA polymerase II transcription subunit 13

1

8

Small-scale

0.479

High

756463

FRU
Sex determination protein fruitless

1

20

Small-scale

0.479

High

756469

Q8T0D3
Protein DEK

1

6

Small-scale

0.479

High

756482

KDM4A
Probable lysine-specific demethylase 4A

1

15

Small-scale

0.479

High

756483

CSN4
COP9 signalosome complex subunit 4

1

7

Small-scale

0.479

High

756485

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

Small-scale

0.479

High

756487

NUP98
Nuclear pore complex protein Nup98-Nup96

1

20

Small-scale

0.479

High

756490

Q9VGW7
type I protein arginine methyltransferase

1

20

Small-scale

0.479

High

756491

CARM1
Probable histone-arginine methyltransferase CARMER

1

20

Small-scale

0.479

High

756498

Q9VLX0
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

1

Small-scale

0.479

High

756500

MED27
Mediator of RNA polymerase II transcription subunit 27

1

3

Small-scale

0.479

High

756501

MED1
Mediator of RNA polymerase II transcription subunit 1

1

20

Small-scale

0.479

High

756502

Q9VS55
CTCF

1

14

Small-scale

0.479

High

756507

MED12
Mediator of RNA polymerase II transcription subunit 12

1

20

Small-scale

0.479

High

756508

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

15

Small-scale

0.479

High

756511

Q9W1H0
HL01030p

1

20

Small-scale

0.479

High

756515

CSN5
COP9 signalosome complex subunit 5

1

12

Small-scale

0.479

High

756516

MED15
Mediator of RNA polymerase II transcription subunit 15

1

20

Small-scale

0.479

High

756457

SP42D
Serine protease inhibitor 42Dd

1

9

High-throughput

0.464

High

756495

Q9VIF2
GM01519p

1

1

High-throughput

0.464

High

756496

Q9VIH1
CG9273 protein

1

2

High-throughput

0.464

High

756499

POLZ2
DNA polymerase zeta subunit 2

1

1

High-throughput

0.464

High

117958

M9MRJ8
Taiman, isoform E

1

0

Small-scale

0.458

High

2291

A0A0B4KEQ7
Regulatory protein zeste

1

3

High-throughput

0.457

High

2596

A0A0B4KGZ0
Methyl-CpG binding domain protein-like, isoform C

1

5

High-throughput

0.457

High

195961

O17144
Cyclin-H

1

19

High-throughput

0.457

High

756440

MNB
Serine/threonine-protein kinase minibrain

1

20

High-throughput

0.457

High

756443

P91668
Cyclin-dependent kinase inhibitor Dacapo

1

1

High-throughput

0.457

High

756474

Q95R37
SD10969p

1

12

High-throughput

0.457

High

756478

Q961G6
Cyclin-Q

1

17

High-throughput

0.457

High

756479

Q9GTQ8
Cyclin D

1

8

High-throughput

0.457

High

756480

Q9NH11
DNA 3'-5' helicase

1

20

High-throughput

0.457

High

756497

Q9VLW7
Cell division cycle 14, isoform A

1

7

High-throughput

0.457

High

756503

AKIRN
Akirin

1

1

Small-scale

0.457

High

756466

Q8IQX8
histidine--tRNA ligase

1

2

High-throughput

0.445

High

756493

JHD1
JmjC domain-containing histone demethylation protein 1

1

14

High-throughput

0.445

High

756506

Q9VV77
Polycomb group RING finger protein 3

1

14

High-throughput

0.445

High

69205

A8JUS8
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

84844

B7Z0M0
FI17308p1

1

1

High-throughput

0.439

High

756438

PLU
DNA replication inhibitor plutonium

1

20

High-throughput

0.439

High

756451

Q7JQF6
HL05804p

1

0

High-throughput

0.426

High

756458

Q868J0
PLU

1

20

High-throughput

0.417

High

756513

Q9W5G0
LD08762p

1

1

High-throughput

0.417

High

84577

LINT
Serine protease filzig

1

3

High-throughput

0.407

High

305634

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.391

High

756475

Q95RS0
LD10926p

1

0

High-throughput

0.365

High

756462

Q8IGE8
RH36596p

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025