HitPredict

Interactor 1: PRP19 (P32523)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: MSL1 (P40567)
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Gene: MSL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	11884590, 11804584
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Sc			1 111
+	Sp
		144118 PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04		RU2B_SCHPO (28-111): 1.1e-25: 94: 40.00
+	Sp
		144080 PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04		SF3B6_SCHPO (27-103): 2.06e-11: 57.7: 25.64
+	Hs
		903215 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		CIRBP_HUMAN (29-109): 1.33e-25: 95.6: 24.71
+	Hs
		266949 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		SRS10_HUMAN (19-110): 1.18e-24: 95.3: 17.71
+	Hs
		745111 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		RBMX_HUMAN (30-108): 5.87e-12: 62.3: 27.71
+	Hs
		1357322 PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78		PPIE_HUMAN (27-105): 2.02e-23: 93: 26.51
+	Hs
		903430 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		RMXL1_HUMAN (30-108): 1.86e-11: 60.8: 27.71
+	Hs
		921082 GBB1_HUMAN (278-502): 5.72e-36: 138: 11.01		PPIE_HUMAN (27-105): 2.02e-23: 93: 26.51
+	Hs
		446840 PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78		SNRPA_HUMAN (2-106): 3.28e-12: 62.4: 18.52
+	Hs
		1054665 PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78		RBM39_HUMAN (4-109): 9.05e-12: 61.7: 26.36
+	Hs
		196944 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		SNRPA_HUMAN (2-106): 3.28e-12: 62.4: 18.52
+	Hs
		197019 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		RBM39_HUMAN (4-109): 9.05e-12: 61.7: 26.36
+	Hs
		267101 FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51		SRS10_HUMAN (19-110): 1.18e-24: 95.3: 17.71
+	Hs
		920967 GBB1_HUMAN (278-502): 5.72e-36: 138: 11.01		RBM39_HUMAN (4-109): 9.05e-12: 61.7: 26.36
+	Hs
		267038 FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42		SRS10_HUMAN (19-110): 1.18e-24: 95.3: 17.71
+	Hs
		745350 FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51		RBMX_HUMAN (30-108): 5.87e-12: 62.3: 27.71
+	Hs
		1054682 FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51		RBM39_HUMAN (4-109): 9.05e-12: 61.7: 26.36
+	Dm
		1180732 Q7KLW9_DROME (151-317): 7.02e-15: 78.8: 6.47		PPIE_DROME (24-105): 3.93e-23: 92.3: 24.42
+	Hs
		745248 FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42		RBMX_HUMAN (30-108): 5.87e-12: 62.3: 27.71
+	Hs
		1054489 FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42		RBM39_HUMAN (4-109): 9.05e-12: 61.7: 26.36