HitPredict

Interactor 1: PRP19 (P32523)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: SMD3 (P43321)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	11884590, 11804584, 37968396
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 503 Sc			1 101
+	Sc
		692287 PRP19_YEAST (1-503): 7.56e-93: 293: 100.00		LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86
+	Sc
		692303 PRP19_YEAST (1-503): 7.56e-93: 293: 100.00		LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36
+	Sp
		144146 PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04		SMD3_SCHPO (4-101): 1.27e-32: 110: 51.02
+	Sp
		144076 PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04		SMD1_SCHPO (7-96): 1.57e-28: 101: 24.44
+	Hs
		903093 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86
+	Hs
		903646 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29
+	Hs
		903627 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24
+	Hs
		903091 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33
+	Hs
		903090 WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Hs
		196993 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86
+	Hs
		197113 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29
+	Hs
		197110 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24
+	Hs
		911996 PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Hs
		196988 PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Hs
		1377166 FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51		LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29
+	Hs
		912695 FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42		SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86
+	Hs
		912348 FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42		SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33