HitPredict

Interactor 1: RPD3 (P32561)
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)
Gene: RPD3

Interactor 2: RSC4 (Q02206)
Chromatin structure-remodeling complex subunit RSC4 (RSC complex subunit RSC4) (Remodel the structure of chromatin complex subunit 4)
Gene: RSC4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21179020
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006368 - transcription elongation by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Sc			1 625
+	Dm
		116005 HDAC1_DROME (15-432): 0: 586: 59.57		M9PH39_DROME (210-311): 1.36e-29: 127: 31.73
+	Hs
		998668 HDAC1_HUMAN (15-428): 0: 598: 60.87		EP300_HUMAN (4-210): 2.62e-21: 101: 14.35
+	Hs
		600138 HDAC1_HUMAN (15-428): 0: 598: 60.87		TAF1_HUMAN (128-301): 1.03e-20: 99.6: 12.57
+	Sc
		693060 RPD3_YEAST (1-433): 0: 599: 100.00		GCN5_YEAST (5-160): 4.11e-20: 95.3: 16.77
+	Hs
		998937 HDAC2_HUMAN (18-432): 0: 583: 61.69		EP300_HUMAN (4-210): 2.62e-21: 101: 14.35
+	Hs
		1038592 HDAC1_HUMAN (15-428): 0: 598: 60.87		CBP_HUMAN (2-161): 8.96e-14: 77.2: 17.06
+	Mm
		140261 HDAC1_MOUSE (15-428): 0: 598: 61.11		SMCA4_MOUSE (56-148): 2.07e-12: 72.8: 33.33
+	Hs
		846962 HDAC1_HUMAN (15-428): 0: 598: 60.87		SMCA4_HUMAN (56-148): 3.01e-12: 72.1: 33.00
+	Hs
		846768 HDAC1_HUMAN (15-428): 0: 598: 60.87		SMCA2_HUMAN (78-148): 9.33e-12: 70.5: 34.72
+	Hs
		244400 HDAC1_HUMAN (15-428): 0: 598: 60.87		BRD4_HUMAN (79-180): 1.04e-11: 70.2: 19.05
+	Hs
		1270347 HDAC2_HUMAN (18-432): 0: 583: 61.69		CBP_HUMAN (2-161): 8.96e-14: 77.2: 17.06
+	Hs
		847037 HDAC2_HUMAN (18-432): 0: 583: 61.69		SMCA4_HUMAN (56-148): 3.01e-12: 72.1: 33.00
+	Mm
		936385 HDAC2_MOUSE (18-432): 0: 581: 61.45		SMCA4_MOUSE (56-148): 2.07e-12: 72.8: 33.33
+	Hs
		846833 HDAC2_HUMAN (18-432): 0: 583: 61.69		SMCA2_HUMAN (78-148): 9.33e-12: 70.5: 34.72
+	Hs
		244727 HDAC2_HUMAN (18-432): 0: 583: 61.69		BRD4_HUMAN (79-180): 1.04e-11: 70.2: 19.05
+	Hs
		177279 HDAC3_HUMAN (19-433): 0: 534: 57.31		EP300_HUMAN (4-210): 2.62e-21: 101: 14.35
+	Hs
		177346 HDAC3_HUMAN (19-433): 0: 534: 57.31		CBP_HUMAN (2-161): 8.96e-14: 77.2: 17.06
+	Mm
		292413 HDAC3_MOUSE (19-433): 0: 534: 57.31		SMCA4_MOUSE (56-148): 2.07e-12: 72.8: 33.33
+	Hs
		177241 HDAC3_HUMAN (19-433): 0: 534: 57.31		SMCA4_HUMAN (56-148): 3.01e-12: 72.1: 33.00
+	Hs
		177147 HDAC3_HUMAN (19-433): 0: 534: 57.31		BRD4_HUMAN (79-180): 1.04e-11: 70.2: 19.05