Protein: CERS2
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)

Gene: CERS2
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q96G23

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0019216 - regulation of lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1391296

SG196
Protein O-mannose kinase

4

4

High-throughput

0.699

High

1339792

CADM4
Cell adhesion molecule 4

1

1

High-throughput

0.691

High

665665

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

4

1

High-throughput

0.691

High

692247

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

3

1

Small-scale

0.672

High

443920

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

3

3

High-throughput

0.662

High

1251735

CERS6
Ceramide synthase 6

1

7

Small-scale

0.647

High

184023

S22A1
Solute carrier family 22 member 1

2

7

Small-scale

0.619

High

820714

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

1366169

LPAR1
Lysophosphatidic acid receptor 1

3

12

High-throughput

0.609

High

1391326

IR3IP
Immediate early response 3-interacting protein 1

2

1

High-throughput

0.606

High

702825

5HT2C
5-hydroxytryptamine receptor 2C

3

13

High-throughput

0.604

High

1391309

ELOV5
Very long chain fatty acid elongase 5

2

8

Small-scale

0.584

High

1156694

NF2L2
Nuclear factor erythroid 2-related factor 2

1

2

Small-scale

0.582

High

325583

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

461806

HS90A
Heat shock protein HSP 90-alpha

1

3

High-throughput

0.578

High

256111

S19A2
Thiamine transporter 1

2

5

High-throughput

0.576

High

1327496

CERS5
Ceramide synthase 5

1

7

High-throughput

0.575

High

669240

NK1R
Substance-P receptor

2

5

High-throughput

0.574

High

835360

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

8

High-throughput

0.574

High

1159096

C3AR
C3a anaphylatoxin chemotactic receptor

2

20

High-throughput

0.574

High

396701

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

1391290

UN93B
Protein unc-93 homolog B1

2

3

High-throughput

0.571

High

455931

ASGR1
Asialoglycoprotein receptor 1

2

2

Small-scale

0.565

High

455999

ASGR2
Asialoglycoprotein receptor 2

2

4

Small-scale

0.565

High

1391284

B2L13
Bcl-2-like protein 13

1

1

Small-scale

0.552

High

617571

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

2

1

High-throughput

0.549

High

1391314

ATIF1
ATPase inhibitor, mitochondrial

2

1

High-throughput

0.549

High

270473

FZD7
Frizzled-7

1

3

High-throughput

0.536

High

374847

RASH
GTPase HRas

1

1

High-throughput

0.536

High

466052

ANXA6
Annexin A6

1

1

High-throughput

0.536

High

564847

NCAM1
Neural cell adhesion molecule 1

1

1

High-throughput

0.536

High

618478

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

3

High-throughput

0.536

High

680461

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.536

High

699002

CALX
Calnexin

1

2

High-throughput

0.536

High

701424

5HT1B
5-hydroxytryptamine receptor 1B

1

9

High-throughput

0.536

High

784683

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.536

High

932591

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

6

High-throughput

0.536

High

945839

EPIPL
Epiplakin

1

3

High-throughput

0.536

High

1006932

KC1G2
Casein kinase I isoform gamma-2

1

1

High-throughput

0.536

High

1053825

KDSR
3-ketodihydrosphingosine reductase

1

3

High-throughput

0.536

High

1068284

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.536

High

1117441

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.536

High

1121845

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

1134326

IMB1
Importin subunit beta-1

1

3

High-throughput

0.536

High

1291453

RETR3
Reticulophagy regulator 3

1

2

High-throughput

0.536

High

1391280

CML1
Chemerin-like receptor 1

1

19

High-throughput

0.536

High

1391293

TTYH1
Protein tweety homolog 1

1

3

High-throughput

0.536

High

1313793

S15A3
Solute carrier family 15 member 3

2

6

High-throughput

0.521

High

292717

RENR
Renin receptor

1

0

High-throughput

0.513

High

539567

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.513

High

603330

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

932560

GAS1
Growth arrest-specific protein 1

1

0

High-throughput

0.513

High

1088159

CNTN1
Contactin-1

1

0

High-throughput

0.513

High

1091553

DLG1
Disks large homolog 1

1

0

High-throughput

0.513

High

1128989

I5P1
Inositol polyphosphate-5-phosphatase A

1

0

High-throughput

0.513

High

1243296

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.513

High

1273105

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

1

0

High-throughput

0.513

High

1391274

SGCZ
Zeta-sarcoglycan

1

0

High-throughput

0.513

High

1391281

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.513

High

1391285

CEP41
Centrosomal protein of 41 kDa

1

0

High-throughput

0.513

High

508432

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

572459

DRD2
D(2) dopamine receptor

1

9

High-throughput

0.494

High

1112261

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.494

High

1391278

NECD
Necdin

1

0

High-throughput

0.493

High

141854

ACKR2
Atypical chemokine receptor 2

1

11

High-throughput

0.489

High

217504

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.489

High

292468

PALM
Paralemmin-1

1

1

High-throughput

0.489

High

349530

TSN15
Tetraspanin-15

1

4

High-throughput

0.489

High

351943

S1PR4
Sphingosine 1-phosphate receptor 4

1

15

High-throughput

0.489

High

440674

FYN
Tyrosine-protein kinase Fyn

1

3

High-throughput

0.489

High

463193

YES
Tyrosine-protein kinase Yes

1

3

High-throughput

0.489

High

463702

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.489

High

474893

VIME
Vimentin

1

4

High-throughput

0.489

High

477450

CD63
CD63 antigen

1

3

High-throughput

0.489

High

482628

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

2

High-throughput

0.489

High

557428

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.489

High

640449

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

19

High-throughput

0.489

High

659050

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

3

High-throughput

0.489

High

733046

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

8

High-throughput

0.489

High

832441

OPRX
Nociceptin receptor

1

5

High-throughput

0.489

High

862369

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.489

High

868307

P2RY1
P2Y purinoceptor 1

1

15

High-throughput

0.489

High

893518

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

3

High-throughput

0.489

High

930777

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

2

High-throughput

0.489

High

940680

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

1

High-throughput

0.489

High

1053720

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

4

High-throughput

0.489

High

1058911

ZO1
Tight junction protein 1

1

1

High-throughput

0.489

High

1095436

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.489

High

1101626

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

15

High-throughput

0.489

High

1106291

ROCK1
Rho-associated protein kinase 1

1

2

High-throughput

0.489

High

1129360

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

3

High-throughput

0.489

High

1143232

PLEC
Plectin

1

2

High-throughput

0.489

High

1154504

STXB2
Syntaxin-binding protein 2

1

2

High-throughput

0.489

High

1157246

AINX
Alpha-internexin

1

3

High-throughput

0.489

High

1275446

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

1

High-throughput

0.489

High

1308650

AHNK2
Protein AHNAK2

1

1

High-throughput

0.489

High

1330628

CCYL1
Cyclin-Y-like protein 1

1

1

High-throughput

0.489

High

1331346

ENAH
Protein enabled homolog

1

1

High-throughput

0.489

High

1336358

CCNY
Cyclin-Y

1

1

High-throughput

0.489

High

1352044

MICA1
[F-actin]-monooxygenase MICAL1

1

1

High-throughput

0.489

High

1389977

MB12A
Multivesicular body subunit 12A

1

1

High-throughput

0.489

High

1391276

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

2

High-throughput

0.489

High

1391286

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.489

High

1391297

MB12B
Multivesicular body subunit 12B

1

1

High-throughput

0.489

High

1391299

IPPK
Inositol-pentakisphosphate 2-kinase

1

3

High-throughput

0.489

High

1391301

GPR35
G-protein coupled receptor 35

1

17

High-throughput

0.489

High

1391303

GP173
Probable G-protein coupled receptor 173

1

13

High-throughput

0.489

High

1391318

TNF18
Tumor necrosis factor ligand superfamily member 18

1

1

High-throughput

0.489

High

1391319

PLAK2
PALM2-AKAP2 fusion protein

1

1

High-throughput

0.489

High

1391320

E41L3
Band 4.1-like protein 3

1

1

High-throughput

0.489

High

1391323

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.489

High

1391324

TLN1
Talin-1

1

1

High-throughput

0.489

High

1391325

CD2AP
CD2-associated protein

1

1

High-throughput

0.489

High

1391327

KC1G3
Casein kinase I isoform gamma-3

1

1

High-throughput

0.489

High

1391308

S39A1
Zinc transporter ZIP1

1

8

High-throughput

0.481

High

51287

ELOV7
Very long chain fatty acid elongase 7

1

8

Small-scale

0.479

High

174042

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

363707

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

417670

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

418351

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

581227

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.479

High

614721

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

High-throughput

0.479

High

693053

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

847643

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

904064

BAP31
B-cell receptor-associated protein 31

1

5

High-throughput

0.479

High

951345

SC61B
Protein transport protein Sec61 subunit beta

1

4

High-throughput

0.479

High

955468

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

962373

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

980130

H4
Histone H4

1

1

High-throughput

0.479

High

989771

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

3

High-throughput

0.479

High

1136670

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

1

High-throughput

0.479

High

1163391

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

1199233

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

Small-scale

0.479

High

1287407

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

High-throughput

0.479

High

1333946

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1367008

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1381485

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1391277

SEC62
Translocation protein SEC62

1

3

High-throughput

0.479

High

1391283

ELOV1
Very long chain fatty acid elongase 1

1

8

Small-scale

0.479

High

1391289

ELOV4
Very long chain fatty acid elongase 4

1

8

Small-scale

0.479

High

1391295

ELOV6
Very long chain fatty acid elongase 6

1

8

Small-scale

0.479

High

1391298

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1391300

ELOV3
Very long chain fatty acid elongase 3

1

8

Small-scale

0.479

High

1391307

ELOV2
Very long chain fatty acid elongase 2

1

8

Small-scale

0.479

High

1391310

TECR
Very-long-chain enoyl-CoA reductase

1

1

Small-scale

0.479

High

934263

BI1
Bax inhibitor 1

1

0

High-throughput

0.460

High

353497

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

562308

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.458

High

800042

COIL
Coilin

1

0

High-throughput

0.458

High

901999

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

1004960

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1331441

VA0D2
V-type proton ATPase subunit d 2

1

0

High-throughput

0.458

High

1391282

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.458

High

1391288

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1391292

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1391311

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

211164

CTR4
Cationic amino acid transporter 4

1

8

High-throughput

0.445

High

351243

MOT3
Monocarboxylate transporter 3

1

2

High-throughput

0.445

High

722577

CTR1
High affinity cationic amino acid transporter 1

1

8

High-throughput

0.445

High

869649

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

13

High-throughput

0.445

High

870285

S6A12
Sodium- and chloride-dependent betaine transporter

1

13

High-throughput

0.445

High

870399

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

13

High-throughput

0.445

High

1139533

S39AE
Metal cation symporter ZIP14

1

8

High-throughput

0.445

High

1236270

MFSD5
Molybdate-anion transporter

1

3

High-throughput

0.445

High

1242199

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.445

High

1328707

DPP10
Inactive dipeptidyl peptidase 10

1

1

High-throughput

0.445

High

1391287

S19A3
Thiamine transporter 2

1

5

High-throughput

0.445

High

386086

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.437

High

464029

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.437

High

658977

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

3

High-throughput

0.437

High

1142143

P2RY6
P2Y purinoceptor 6

1

17

High-throughput

0.437

High

1238774

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1255042

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1288558

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.437

High

1391273

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1391294

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1391305

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

1391312

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

66387

T238L
Transmembrane protein 238-like

1

0

Small-scale

0.426

High

1348296

GOGA5
Golgin subfamily A member 5

1

0

High-throughput

0.426

High

66070

RP1BL
Ras-related protein Rap-1b-like protein

1

1

High-throughput

0.407

High

1211946

S35F1
Solute carrier family 35 member F1

1

9

High-throughput

0.407

High

1308934

S22A9
Organic anion transporter 7

1

7

High-throughput

0.407

High

1337904

ZNT7
Zinc transporter 7

1

6

High-throughput

0.407

High

1340551

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.407

High

1391272

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

1

High-throughput

0.407

High

1391302

S35C2
Solute carrier family 35 member C2

1

3

High-throughput

0.407

High

63248

VP37C
Vacuolar protein sorting-associated protein 37C

1

0

High-throughput

0.279

Low

124089

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.279

Low

125900

ARVC
Splicing regulator ARVCF

1

0

High-throughput

0.279

Low

252475

DIAP1
Protein diaphanous homolog 1

1

0

High-throughput

0.279

Low

281774

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.279

Low

607313

NEUM
Neuromodulin

1

0

High-throughput

0.279

Low

716717

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.279

Low

914551

EFNA5
Ephrin-A5

1

0

High-throughput

0.279

Low

928804

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

0

High-throughput

0.279

Low

1035432

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

0

High-throughput

0.279

Low

1107457

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

High-throughput

0.279

Low

1131458

RFTN1
Raftlin

1

0

High-throughput

0.279

Low

1158073

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

High-throughput

0.279

Low

1233413

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.279

Low

1243099

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1308001

RELL1
RELT-like protein 1

1

0

High-throughput

0.279

Low

1314138

RAVR1
Ribonucleoprotein PTB-binding 1

1

0

High-throughput

0.279

Low

1346849

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.279

Low

1363267

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.279

Low

1382443

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.279

Low

1390809

CPNE2
Copine-2

1

0

High-throughput

0.279

Low

1391275

PRRC1
Protein PRRC1

1

0

High-throughput

0.279

Low

1391279

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.279

Low

1391291

CA021
Uncharacterized protein C1orf21

1

0

High-throughput

0.279

Low

1391306

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.279

Low

1391315

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.279

Low

1391316

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.279

Low

1391317

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

0

High-throughput

0.279

Low

1391322

CHMP3
Charged multivesicular body protein 3

1

0

High-throughput

0.279

Low

138271

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

164416

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

246092

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.249

Low

296861

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

0

High-throughput

0.249

Low

675108

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

995194

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.249

Low

1121970

ARHG7
Rho guanine nucleotide exchange factor 7

1

0

High-throughput

0.249

Low

1229624

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1276632

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1322940

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1391304

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1391313

UBQL2
Ubiquilin-2

1

0

High-throughput

0.249

Low

337648

GNAS3
Neuroendocrine secretory protein 55

1

0

High-throughput

0.232

Low

1331236

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.232

Low

1391321

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025