HitPredict

Interactor 1: HSP7F (P32589)
Heat shock protein homolog SSE1 (Chaperone protein MSI3)
Gene: SSE1

Interactor 2: HST3 (P53687)
NAD-dependent histone deacetylase HST3 (EC 2.3.1.286) (Homologous to SIR2 protein 3) (Regulatory protein SIR2 homolog 3)
Gene: HST3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 693 Sc			1 447
+	Sc
		416210 HSP79_YEAST (1-677): 0: 992: 77.11		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Hs
		714048 HS71L_HUMAN (2-646): 0: 848: 26.69		SIR1_HUMAN (31-431): 8.75e-104: 326: 25.78
+	Hs
		714080 HS71L_HUMAN (2-646): 0: 848: 26.69		SIR3_HUMAN (36-367): 1.25e-88: 277: 25.89
+	Hs
		504364 HSP7C_HUMAN (2-645): 0: 851: 27.04		SIR2_HUMAN (37-391): 2.72e-86: 270: 26.79
+	Sc
		416209 HSP7F_YEAST (1-693): 0: 829: 100.00		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Hs
		871799 HSP72_HUMAN (2-644): 0: 840: 27.08		SIR7_HUMAN (8-392): 1.15e-84: 266: 20.10
+	Hs
		504402 HSP7C_HUMAN (2-645): 0: 851: 27.04		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Hs
		714019 HS71L_HUMAN (2-646): 0: 848: 26.69		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Sc
		695211 HSP7F_YEAST (1-693): 0: 829: 100.00		HST2_YEAST (39-425): 1.88e-78: 249: 19.21
+	Hs
		871671 HSP72_HUMAN (2-644): 0: 840: 27.08		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Sc
		494586 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		HST3_YEAST (1-447): 0: 539: 100.00
+	Hs
		714355 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		SIR1_HUMAN (31-431): 8.75e-104: 326: 25.78
+	Hs
		714434 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		SIR3_HUMAN (36-367): 1.25e-88: 277: 25.89
+	Hs
		714433 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		SIR7_HUMAN (8-392): 1.15e-84: 266: 20.10
+	Hs
		714307 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Hs
		320882 HS74L_HUMAN (6-650): 1.32e-134: 418: 35.85		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Sc
		416182 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Sc
		416181 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Sc
		491991 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		HST1_YEAST (26-362): 2.14e-90: 284: 27.22
+	Sc
		494587 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		HST4_YEAST (45-340): 6.4e-87: 271: 33.55