HitPredict

Interactor 1: SEC17 (P32602)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (Vesicular-fusion protein SEC17) (alpha-SNAP chaperone)
Gene: SEC17

Interactor 2: TLG1 (Q03322)
t-SNARE affecting a late Golgi compartment protein 1 (Syntaxin TLG1)
Gene: TLG1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	9427746, 10397773
Identification Methods	coimmunoprecipitation, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0031201 - SNARE complex GO:0048280 - vesicle fusion with Golgi apparatus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Sc			1 224
+	Zm
		39691 A0A1D6PZ82_MAIZE (2-269): 6.86e-90: 272: 29.85		A0A1D6N0J7_MAIZE (1-224): 1.77e-61: 195: 19.17
+	Hs
		235158 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX10_HUMAN (3-208): 2.07e-49: 163: 17.95
+	Hs
		212995 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX6_HUMAN (3-208): 1.47e-48: 161: 17.65
+	Hs
		212779 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX6_HUMAN (3-208): 1.47e-48: 161: 17.65
+	Dm
		1095586 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q9VV76_DROME (6-210): 8.2e-40: 138: 15.28
+	Hs
		873597 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX8_HUMAN (6-205): 5.98e-29: 110: 12.79
+	Hs
		169605 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		BET1_HUMAN (118-223): 2.86e-26: 99.9: 14.15
+	Hs
		169421 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		BET1_HUMAN (118-223): 2.86e-26: 99.9: 14.15
+	Sc
		696560 SEC17_YEAST (1-292): 5.94e-97: 288: 100.00		VAM7_YEAST (8-198): 1.6e-25: 102: 17.71
+	Dm
		1095557 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q5BI25_DROME (13-132): 2.57e-19: 86.8: 15.56
+	Dm
		1095587 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q9VVX6_DROME (147-224): 2.69e-20: 84.5: 16.67
+	Hs
		235208 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		STX10_HUMAN (3-208): 2.07e-49: 163: 17.95
+	Hs
		212982 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		STX6_HUMAN (3-208): 1.47e-48: 161: 17.65
+	Hs
		873588 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		BET1L_HUMAN (136-220): 3.03e-10: 57.5: 18.18
+	Sc
		611768 SEC17_YEAST (1-292): 5.94e-97: 288: 100.00		BET1_YEAST (90-224): 1.11e-10: 59.4: 12.32
+	Dm
		1353750 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		Q9VV76_DROME (6-210): 8.2e-40: 138: 15.28
+	Hs
		1306217 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		STX8_HUMAN (6-205): 5.98e-29: 110: 12.79
+	Dm
		1366628 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		Q9VV76_DROME (6-210): 8.2e-40: 138: 15.28
+	Hs
		169588 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		BET1_HUMAN (118-223): 2.86e-26: 99.9: 14.15
+	Dm
		1353751 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		Q9VVX6_DROME (147-224): 2.69e-20: 84.5: 16.67