Protein: RTN3
Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)

Gene: RTN3
Organism: Homo sapiens
Interactions: 243
UniProt ID: O95197

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329017

RTN4
Reticulon-4

8

16

High-throughput

0.752

High

328833

RTN3
Reticulon-3

3

16

Small-scale

0.669

High

329039

CERT
Ceramide transfer protein

3

1

High-throughput

0.666

High

328873

PTN9
Tyrosine-protein phosphatase non-receptor type 9

5

4

High-throughput

0.659

High

328990

ESYT1
Extended synaptotagmin-1

3

7

High-throughput

0.650

High

329019

SAC1
Phosphatidylinositol-3-phosphatase SAC1

3

2

High-throughput

0.647

High

329014

GPR35
G-protein coupled receptor 35

2

9

High-throughput

0.633

High

328933

ATLA3
Atlastin-3

2

11

High-throughput

0.628

High

329036

GOT1B
Vesicle transport protein GOT1B

2

2

High-throughput

0.628

High

328901

REEP5
Receptor expression-enhancing protein 5

2

6

High-throughput

0.611

High

328902

IFM3
Interferon-induced transmembrane protein 3

2

5

High-throughput

0.611

High

328917

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

2

High-throughput

0.611

High

328944

RETR3
Reticulophagy regulator 3

2

5

Small-scale

0.611

High

328945

TEX2
Testis-expressed protein 2

2

2

High-throughput

0.611

High

328946

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

1

High-throughput

0.606

High

328960

GP152
Probable G-protein coupled receptor 152

2

14

High-throughput

0.606

High

328986

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

1

High-throughput

0.606

High

48471

ESYT2
Extended synaptotagmin-2

2

7

High-throughput

0.601

High

275475

RTN2
Reticulon-2

2

15

High-throughput

0.601

High

328924

DHC24
Delta(24)-sterol reductase

2

3

High-throughput

0.601

High

328954

F241A
Uncharacterized protein FAM241A

2

3

High-throughput

0.601

High

328969

LRC59
Leucine-rich repeat-containing protein 59

2

4

High-throughput

0.584

High

328984

SEC62
Translocation protein SEC62

2

2

High-throughput

0.584

High

328860

PPLA
Phospholamban

2

0

High-throughput

0.580

High

328979

RMD2
Regulator of microtubule dynamics protein 2

2

0

High-throughput

0.580

High

162140

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.573

High

328912

SNX1
Sorting nexin-1

1

3

High-throughput

0.573

High

327706

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

4

Small-scale

0.571

High

328884

BAP31
B-cell receptor-associated protein 31

2

3

High-throughput

0.571

High

328955

DHB11
Estradiol 17-beta-dehydrogenase 11

2

10

High-throughput

0.571

High

328997

LNP
Endoplasmic reticulum junction formation protein lunapark

2

6

High-throughput

0.571

High

328966

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.549

High

328853

DRD2
D(2) dopamine receptor

1

6

High-throughput

0.541

High

328865

AGTR1
Type-1 angiotensin II receptor

1

10

High-throughput

0.541

High

328869

CCR2
C-C chemokine receptor type 2

1

7

High-throughput

0.541

High

328879

FXR2
RNA-binding protein FXR2

1

1

High-throughput

0.541

High

328885

CCR8
C-C chemokine receptor type 8

1

6

High-throughput

0.541

High

328913

RB33A
Ras-related protein Rab-33A

1

14

High-throughput

0.541

High

328995

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.541

High

329013

PKHF2
Pleckstrin homology domain-containing family F member 2

1

5

High-throughput

0.541

High

329032

NDRG4
Protein NDRG4

1

3

High-throughput

0.541

High

129941

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

158072

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.536

High

178876

SCAM2
Secretory carrier-associated membrane protein 2

1

4

High-throughput

0.536

High

261028

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.536

High

297124

PRAF3
PRA1 family protein 3

1

10

High-throughput

0.536

High

328834

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

7

High-throughput

0.536

High

328836

TSN15
Tetraspanin-15

1

4

High-throughput

0.536

High

328864

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.536

High

328868

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.536

High

328882

MMP15
Matrix metalloproteinase-15

1

1

High-throughput

0.536

High

328887

COPA
Coatomer subunit alpha

1

6

High-throughput

0.536

High

328889

BACE1
Beta-secretase 1

1

2

Small-scale

0.536

High

328893

COPZ1
Coatomer subunit zeta-1

1

2

High-throughput

0.536

High

328903

KDSR
3-ketodihydrosphingosine reductase

1

12

High-throughput

0.536

High

328930

RTN1
Reticulon-1

1

17

High-throughput

0.536

High

328952

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.536

High

328980

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

1

High-throughput

0.536

High

328981

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.536

High

328985

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

High-throughput

0.536

High

328992

TM208
Transmembrane protein 208

1

3

High-throughput

0.536

High

328998

DERL2
Derlin-2

1

7

High-throughput

0.536

High

329009

SG196
Protein O-mannose kinase

1

5

High-throughput

0.536

High

329010

REEP4
Receptor expression-enhancing protein 4

1

6

High-throughput

0.536

High

329024

VAPA
Vesicle-associated membrane protein-associated protein A

1

7

High-throughput

0.536

High

329026

COPG2
Coatomer subunit gamma-2

1

5

High-throughput

0.536

High

329028

PRAF1
Prenylated Rab acceptor protein 1

1

14

High-throughput

0.536

High

329037

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.536

High

329038

TBL2
Transducin beta-like protein 2

1

4

High-throughput

0.536

High

328888

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.523

High

328976

REEP6
Receptor expression-enhancing protein 6

1

6

High-throughput

0.515

High

328926

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

328965

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

328987

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.513

High

329003

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.513

High

329016

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.513

High

329025

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

227285

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.494

High

328951

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

1

High-throughput

0.494

High

165499

SCAM3
Secretory carrier-associated membrane protein 3

1

4

High-throughput

0.489

High

186394

TM9S1
Transmembrane 9 superfamily member 1

1

2

High-throughput

0.489

High

328866

1433B
14-3-3 protein beta/alpha

1

4

High-throughput

0.489

High

328894

1433G
14-3-3 protein gamma

1

4

High-throughput

0.489

High

328936

LTMD1
LETM1 domain-containing protein 1

1

4

High-throughput

0.489

High

328972

F241B
Protein FAM241B

1

1

High-throughput

0.489

High

328973

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.489

High

328993

TMM70
Transmembrane protein 70, mitochondrial

1

2

High-throughput

0.489

High

329030

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

3

High-throughput

0.489

High

328851

FGFR1
Fibroblast growth factor receptor 1

1

4

Small-scale

0.481

High

328871

GLP1R
Glucagon-like peptide 1 receptor

1

1

Small-scale

0.481

High

328929

CEGT
Ceramide glucosyltransferase

1

1

Small-scale

0.481

High

173809

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.479

High

217650

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

240358

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

328837

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

328840

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

328841

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

328842

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

328846

VIME
Vimentin

1

2

High-throughput

0.479

High

328847

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.479

High

328854

RAC2
Ras-related C3 botulinum toxin substrate 2

1

13

High-throughput

0.479

High

328856

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.479

High

328857

RAB3B
Ras-related protein Rab-3B

1

15

High-throughput

0.479

High

328858

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

328872

SSRA
Translocon-associated protein subunit alpha

1

3

High-throughput

0.479

High

328878

EMD
Emerin

1

2

High-throughput

0.479

High

328880

RAB7A
Ras-related protein Rab-7a

1

16

High-throughput

0.479

High

328881

RAB9A
Ras-related protein Rab-9A

1

18

High-throughput

0.479

High

328890

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

328891

CDC42
Cell division control protein 42 homolog

1

15

High-throughput

0.479

High

328892

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

328896

RB11A
Ras-related protein Rab-11A

1

8

High-throughput

0.479

High

328905

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.479

High

328906

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

328908

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

328909

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

328911

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

328921

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

328935

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

328938

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

328942

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

High-throughput

0.479

High

328943

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

328949

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

328977

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

328994

DERL1
Derlin-1

1

7

High-throughput

0.479

High

329001

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.479

High

329002

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

5

High-throughput

0.479

High

329011

RETR1
Reticulophagy regulator 1

1

5

Small-scale

0.479

High

329012

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.479

High

329018

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

329031

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

Small-scale

0.479

High

329033

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

329040

BACE2
Beta-secretase 2

1

2

Small-scale

0.479

High

328934

Q6IQ43
Tyrosine-protein phosphatase non-receptor type 9

1

4

High-throughput

0.470

High

328850

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

328971

OPTN
Optineurin

1

0

High-throughput

0.458

High

328982

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

329008

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

50466

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

60280

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.445

High

104311

F5H6I7
Atlastin GTPase 3

1

11

High-throughput

0.445

High

211100

CTR4
Cationic amino acid transporter 4

1

5

High-throughput

0.445

High

211705

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.445

High

215472

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.445

High

254697

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

255948

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

283168

ERLN1
Erlin-1

1

3

High-throughput

0.445

High

328838

NB5R3
NADH-cytochrome b5 reductase 3

1

3

High-throughput

0.445

High

328848

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

328849

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

328852

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

4

High-throughput

0.445

High

328859

FPR2
N-formyl peptide receptor 2

1

7

High-throughput

0.445

High

328862

CALR
Calreticulin

1

7

High-throughput

0.445

High

328863

CALX
Calnexin

1

7

High-throughput

0.445

High

328874

COPD
Coatomer subunit delta

1

2

High-throughput

0.445

High

328877

TMEDA
Transmembrane emp24 domain-containing protein 10

1

8

High-throughput

0.445

High

328883

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.445

High

328886

COPB
Coatomer subunit beta

1

2

High-throughput

0.445

High

328897

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.445

High

328899

NUCB2
Nucleobindin-2

1

2

High-throughput

0.445

High

328900

ARF5
ADP-ribosylation factor 5

1

5

High-throughput

0.445

High

328907

PRDX4
Peroxiredoxin-4

1

4

High-throughput

0.445

High

328915

GANAB
Neutral alpha-glucosidase AB

1

3

High-throughput

0.445

High

328916

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.445

High

328918

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

2

High-throughput

0.445

High

328919

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

328922

RCN1
Reticulocalbin-1

1

2

High-throughput

0.445

High

328923

TMED2
Transmembrane emp24 domain-containing protein 2

1

8

High-throughput

0.445

High

328925

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

5

High-throughput

0.445

High

328928

VACHT
Vesicular acetylcholine transporter

1

1

High-throughput

0.445

High

328931

SOAT
Sodium-dependent organic anion transporter

1

1

High-throughput

0.445

High

328932

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

10

High-throughput

0.445

High

328937

LCLT1
Lysocardiolipin acyltransferase 1

1

2

High-throughput

0.445

High

328948

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

5

High-throughput

0.445

High

328950

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

2

High-throughput

0.445

High

328953

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.445

High

328956

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.445

High

328958

ATLA2
Atlastin-2

1

11

High-throughput

0.445

High

328959

MCFD2
Multiple coagulation factor deficiency protein 2

1

2

High-throughput

0.445

High

328962

SCFD1
Sec1 family domain-containing protein 1

1

3

High-throughput

0.445

High

328963

ATLA1
Atlastin-1

1

11

High-throughput

0.445

High

328967

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.445

High

328970

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

328978

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.445

High

328989

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.445

High

328991

NDC1
Nucleoporin NDC1

1

2

High-throughput

0.445

High

328996

WDR11
WD repeat-containing protein 11

1

2

High-throughput

0.445

High

329004

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

5

High-throughput

0.445

High

329005

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

2

High-throughput

0.445

High

329006

TMX1
Thioredoxin-related transmembrane protein 1

1

7

High-throughput

0.445

High

329020

TM38B
Trimeric intracellular cation channel type B

1

2

High-throughput

0.445

High

329022

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.445

High

329023

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.445

High

329034

DHRS7
Dehydrogenase/reductase SDR family member 7

1

9

High-throughput

0.445

High

329035

TMED5
Transmembrane emp24 domain-containing protein 5

1

8

High-throughput

0.445

High

329042

COPG1
Coatomer subunit gamma-1

1

5

High-throughput

0.445

High

328839

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.439

High

328904

MEF2C
Myocyte-specific enhancer factor 2C

1

0

High-throughput

0.438

High

105005

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

291157

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.437

High

294805

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

4

High-throughput

0.437

High

328835

RIGI
Antiviral innate immune response receptor RIG-I

1

4

Small-scale

0.437

High

328855

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

328861

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

328867

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

328870

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.437

High

328898

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

328927

CCDC6
Coiled-coil domain-containing protein 6

1

2

High-throughput

0.437

High

328939

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

328940

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

328968

S2546
Mitochondrial outer membrane protein SLC25A46

1

2

High-throughput

0.437

High

328974

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

328843

B3A2
Anion exchange protein 2

1

0

High-throughput

0.426

High

213546

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

2

High-throughput

0.407

High

296408

STAM2
Signal transducing adapter molecule 2

1

3

High-throughput

0.407

High

318937

MICA2
[F-actin]-monooxygenase MICAL2

1

5

High-throughput

0.407

High

328845

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.407

High

328875

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.407

High

328876

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.407

High

328941

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

High-throughput

0.407

High

328947

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.407

High

328957

VP37A
Vacuolar protein sorting-associated protein 37A

1

2

High-throughput

0.407

High

328975

TM169
Transmembrane protein 169

1

3

High-throughput

0.407

High

328983

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.407

High

328988

PXL2A
Peroxiredoxin-like 2A

1

3

High-throughput

0.407

High

329000

RGAP1
Rac GTPase-activating protein 1

1

4

High-throughput

0.407

High

329015

APMAP
Adipocyte plasma membrane-associated protein

1

3

High-throughput

0.407

High

329021

GPTC2
G patch domain-containing protein 2

1

2

High-throughput

0.407

High

329027

PARP2
Poly [ADP-ribose] polymerase 2

1

1

Small-scale

0.407

High

329041

SERC
Phosphoserine aminotransferase

1

2

High-throughput

0.407

High

329007

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.373

High

328961

MITD1
MIT domain-containing protein 1

2

0

High-throughput

0.316

High

328964

SNX19
Sorting nexin-19

1

0

High-throughput

0.279

Low

329029

ZN391
Zinc finger protein 391

1

0

High-throughput

0.251

Low

48323

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.249

Low

172359

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

328844

PROF1
Profilin-1

1

0

High-throughput

0.249

Low

328895

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

328910

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.249

Low

328914

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

Small-scale

0.249

Low

328920

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

328999

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025