HitPredict

Interactor 1: BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)
Gene: BRR2

Interactor 2: SMD3 (P43321)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

Property	Details
Experiments	10377396, 25670679, 11720284, 10449419, 16554755, 16429126, 37968396
Identification Methods	biochemical, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005682 - U5 snRNP GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2163 Sc			1 101
+	Hs
		272092 U520_HUMAN (16-2163): 0: 1597: 38.84		SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86
+	Hs
		272319 U520_HUMAN (16-2163): 0: 1597: 38.84		LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29
+	Hs
		272315 U520_HUMAN (16-2163): 0: 1597: 38.84		LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24
+	Hs
		272089 U520_HUMAN (16-2163): 0: 1597: 38.84		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Sc
		697202 BRR2_YEAST (1-2163): 0: 1534: 100.00		LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86
+	Sc
		697214 BRR2_YEAST (1-2163): 0: 1534: 100.00		LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36
+	Sp
		1358076 BRR2_SCHPO (5-2162): 0: 1396: 41.00		SMD3_SCHPO (4-101): 1.27e-32: 110: 51.02
+	Sp
		193913 BRR2_SCHPO (5-2162): 0: 1396: 41.00		SMD1_SCHPO (7-96): 1.57e-28: 101: 24.44
+	Sp
		143227 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		SMD3_SCHPO (4-101): 1.27e-32: 110: 51.02
+	Sp
		143004 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		LSM4_SCHPO (6-92): 2.72e-29: 103: 30.68
+	Hs
		571387 DDX5_HUMAN (1344-1752): 6.23e-93: 317: 11.35		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Sp
		143007 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		SMD1_SCHPO (7-96): 1.57e-28: 101: 24.44
+	Hs
		1313233 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29
+	Hs
		912721 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86
+	Sp
		143067 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		LSM2_SCHPO (9-98): 1.41e-27: 98.1: 16.30
+	Hs
		1313225 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24
+	Hs
		912370 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33
+	Hs
		911952 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87
+	Sc
		622320 PRP22_YEAST (1343-1825): 7.15e-45: 180: 10.74		SMD3_YEAST (1-101): 1.39e-34: 115: 100.00
+	Hs
		912294 DHX8_HUMAN (1353-1741): 3.82e-48: 191: 11.31		SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33