HitPredict

Interactor 1: DLGP4 (B1AZP2)
Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)
Gene: Dlgap4

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	27507650, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 992 Mm			1 1730
+	Hs
		1316315 DLGP4_HUMAN (1-992): 0: 1255: 96.88		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		1116115 DLGP1_MOUSE (1-992): 0: 1211: 45.89		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Rn
		956996 DLGP1_RAT (1-992): 0: 1219: 46.19		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Hs
		145954 DLGP1_HUMAN (1-992): 0: 1233: 46.93		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Hs
		1357785 DLGP4_HUMAN (1-992): 0: 1255: 96.88		SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52
+	Mm
		1116003 DLGP2_MOUSE (1-992): 0: 1087: 41.10		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		145956 DLGP1_HUMAN (1-992): 0: 1233: 46.93		SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52
+	Hs
		1316300 DLGP2_HUMAN (1-992): 0: 1084: 42.87		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		1160650 DLGP1_MOUSE (1-992): 0: 1211: 45.89		CSKI1_MOUSE (55-1397): 7.52e-114: 397: 15.53
+	Rn
		102520 G3V7T8_RAT (1-992): 0: 989: 35.02		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Hs
		327247 DLGP3_HUMAN (1-992): 0: 1005: 35.45		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		1115961 DLGP3_MOUSE (1-992): 0: 979: 35.02		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		1349917 DLGP2_HUMAN (1-992): 0: 1084: 42.87		SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52
+	Rn
		956997 DLGP1_RAT (1-992): 0: 1219: 46.19		SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92
+	Mm
		1194593 DLGP1_MOUSE (1-992): 0: 1211: 45.89		SHAN2_MOUSE (352-1727): 1.03e-90: 328: 35.55
+	Hs
		327248 DLGP3_HUMAN (1-992): 0: 1005: 35.45		SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52
+	Rn
		956998 DLGP1_RAT (1-992): 0: 1219: 46.19		SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14
+	Mm
		88376 DLGP1_MOUSE (1-992): 0: 1211: 45.89		SHAN1_MOUSE (367-1725): 5.86e-28: 126: 14.36
+	Hs
		145958 DLGP1_HUMAN (1-992): 0: 1233: 46.93		SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37
+	Rn
		957003 DLGP2_RAT (1-992): 0: 1096: 41.58		SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14