HitPredict

Interactor 1: STX1A (P32851)
Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A)
Gene: STX1A

Interactor 2: STXB1 (P61765)
Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1)
Gene: Stxbp1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 23962429, 7768895, 8108429, 21266332, 8996080, 22411134, 21193638, 26876096, 17301226, 10746715, 26359495, 18337752
Identification Methods affinity chromatography technology, two hybrid, pull down, isothermal titration calorimetry, electron paramagnetic resonance, cross-linking study, x-ray crystallography, anti tag coimmunoprecipitation, fluorescence technology
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SNARE~Sec1, Sec1~Syntaxin
Common GO terms GO:0000149 - SNARE binding
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0006887 - exocytosis
GO:0010807 - regulation of synaptic vesicle priming
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 288
Rn

1 594
+ Mm
+ Mm
+ Bt
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
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+ Hs
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+ Hs
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+ Dm
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+ Ce
+ Hs
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024