Protein: I17RA
Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)

Gene: I17RA, IL17RA
Organism: Homo sapiens
Interactions: 158
UniProt ID: Q96F46

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158652

IL17
Interleukin-17A

8

8

Small-scale

0.964

High

225427

CIKS
E3 ubiquitin ligase TRAF3IP2

6

2

Small-scale

0.935

High

1390338

IL17F
Interleukin-17F

2

8

Small-scale

0.754

High

1390374

PRG3
Proteoglycan 3

3

1

High-throughput

0.662

High

1362046

DNS2B
Deoxyribonuclease-2-beta

4

0

High-throughput

0.661

High

168445

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

1390350

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

1248783

LYZL1
Lysozyme-like protein 1

2

1

High-throughput

0.628

High

1332612

I17RC
Interleukin-17 receptor C

1

7

Small-scale

0.618

High

1339374

I17RD
Interleukin-17 receptor D

1

3

Small-scale

0.618

High

1339478

I17RE
Interleukin-17 receptor E

1

3

Small-scale

0.618

High

1390351

IL25
Interleukin-25

1

8

Small-scale

0.618

High

1390376

TRAF6
TNF receptor-associated factor 6

2

5

Small-scale

0.612

High

1219214

SUSD4
Sushi domain-containing protein 4

2

0

High-throughput

0.585

High

1094952

TRAF3
TNF receptor-associated factor 3

2

5

Small-scale

0.584

High

976847

LCN6
Epididymal-specific lipocalin-6

2

0

High-throughput

0.576

High

240204

KLK8
Kallikrein-8

1

4

High-throughput

0.536

High

282857

CRLF1
Cytokine receptor-like factor 1

1

1

High-throughput

0.536

High

289330

FCN3
Ficolin-3

1

1

High-throughput

0.536

High

351794

LGI1
Leucine-rich glioma-inactivated protein 1

1

1

High-throughput

0.536

High

455659

KLK3
Prostate-specific antigen

1

4

High-throughput

0.536

High

567950

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.536

High

593468

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.536

High

628444

KLK2
Kallikrein-2

1

4

High-throughput

0.536

High

643386

OSBP1
Oxysterol-binding protein 1

1

1

High-throughput

0.536

High

663566

CMA1
Chymase

1

4

High-throughput

0.536

High

935781

MFAP4
Microfibril-associated glycoprotein 4

1

1

High-throughput

0.536

High

1030207

IL5RA
Interleukin-5 receptor subunit alpha

1

2

High-throughput

0.536

High

1101298

SLAF1
Signaling lymphocytic activation molecule

1

1

High-throughput

0.536

High

1124518

MAP7
Ensconsin

1

1

High-throughput

0.536

High

1278872

LYZL2
Lysozyme-like protein 2

1

1

High-throughput

0.536

High

213994

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.515

High

65950

LIRA5
Leukocyte immunoglobulin-like receptor subfamily A member 5

1

0

High-throughput

0.513

High

154859

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.513

High

155492

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.513

High

188338

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.513

High

253451

CST8
Cystatin-8

1

0

High-throughput

0.513

High

316685

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

327076

NXPH3
Neurexophilin-3

1

0

High-throughput

0.513

High

342641

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.513

High

426125

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.513

High

506893

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

570708

EDN3
Endothelin-3

1

0

High-throughput

0.513

High

651606

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.513

High

714643

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

0

High-throughput

0.513

High

880054

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

933208

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

946255

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

0

High-throughput

0.513

High

997081

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1120641

DAG1
Dystroglycan 1

1

0

High-throughput

0.513

High

1191462

GRDN
Girdin

1

0

High-throughput

0.513

High

1195486

PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

1

0

High-throughput

0.513

High

1246924

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

1248252

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

1248570

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

1248877

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

1

0

High-throughput

0.513

High

1250922

ZPBP2
Zona pellucida-binding protein 2

1

0

High-throughput

0.513

High

1279821

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.513

High

1286780

KAISO
Transcriptional regulator Kaiso

1

0

High-throughput

0.513

High

1308282

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.513

High

1311371

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.513

High

1324265

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.513

High

1333760

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

1335840

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

0

High-throughput

0.513

High

1369041

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1380390

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.513

High

1384583

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.513

High

1390339

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1390359

CBLN4
Cerebellin-4

1

0

High-throughput

0.513

High

1390368

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.513

High

1390371

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.513

High

224514

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.489

High

261433

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

1

High-throughput

0.489

High

404320

GCR
Glucocorticoid receptor

1

1

High-throughput

0.489

High

597808

CRIS2
Cysteine-rich secretory protein 2

1

1

High-throughput

0.489

High

699000

CALX
Calnexin

1

1

High-throughput

0.489

High

790169

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

1

High-throughput

0.489

High

908158

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

High-throughput

0.489

High

1146452

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.489

High

1148376

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.489

High

1179919

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

1

High-throughput

0.489

High

1225862

WDR25
WD repeat-containing protein 25

1

1

High-throughput

0.489

High

1238360

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.489

High

1243033

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.489

High

1250636

BCOR
BCL-6 corepressor

1

1

High-throughput

0.489

High

1293979

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.489

High

1294480

VRK2
Serine/threonine-protein kinase VRK2

1

3

High-throughput

0.489

High

1390336

DDX11
ATP-dependent DNA helicase DDX11

1

2

High-throughput

0.489

High

1390340

MA7D2
MAP7 domain-containing protein 2

1

1

High-throughput

0.489

High

1390345

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.489

High

1390347

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.489

High

1390348

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

1

High-throughput

0.489

High

1390352

KLK15
Kallikrein-15

1

3

High-throughput

0.489

High

1390360

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

1

High-throughput

0.489

High

1390369

TAOK2
Serine/threonine-protein kinase TAO2

1

1

High-throughput

0.489

High

1390373

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.489

High

849221

KSYK
Tyrosine-protein kinase SYK

1

1

Small-scale

0.479

High

1113972

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1390358

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

1177180

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.445

High

70013

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

2

High-throughput

0.407

High

1257803

ACD11
Acyl-CoA dehydrogenase family member 11

2

0

High-throughput

0.328

High

1390366

FBX2
F-box only protein 2

2

0

High-throughput

0.313

High

213639

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.279

Low

252139

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.279

Low

278403

NCOR1
Nuclear receptor corepressor 1

1

0

High-throughput

0.279

Low

286576

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

322443

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

335366

CCN6
Cellular communication network factor 6

1

0

High-throughput

0.279

Low

1390356

PKHA5
Pleckstrin homology domain-containing family A member 5

1

0

High-throughput

0.279

Low

337796

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

399724

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

0

High-throughput

0.279

Low

450263

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

647394

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.279

Low

843858

HD
Huntingtin

1

0

High-throughput

0.279

Low

1010512

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1085458

SRBP2
Sterol regulatory element-binding protein 2

1

0

High-throughput

0.279

Low

1097864

STX5
Syntaxin-5

1

0

High-throughput

0.279

Low

1103569

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.279

Low

1105540

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

1129564

ESPL1
Separin

1

0

High-throughput

0.279

Low

1140129

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

1194701

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1212438

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.279

Low

1218211

ZN318
Zinc finger protein 318

1

0

High-throughput

0.279

Low

1225998

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.279

Low

1253703

CO039
Uncharacterized protein C15orf39

1

0

High-throughput

0.279

Low

1258164

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.279

Low

1279277

PODN
Podocan

1

0

High-throughput

0.279

Low

1280071

FRMD5
FERM domain-containing protein 5

1

0

High-throughput

0.279

Low

1286644

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.279

Low

1290467

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

1313217

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.279

Low

1336157

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1336969

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.279

Low

1353404

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.279

Low

1353780

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

1390337

CE034
Uncharacterized protein C5orf34

1

0

High-throughput

0.279

Low

1390341

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1390342

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1390343

TALD3
Protein TALPID3

1

0

High-throughput

0.279

Low

1390344

CA043
Protein C1orf43

1

0

High-throughput

0.279

Low

1390346

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

1390349

SIK2
Serine/threonine-protein kinase SIK2

1

0

High-throughput

0.279

Low

1390353

TBB1
Tubulin beta-1 chain

1

0

High-throughput

0.279

Low

1390354

ZN644
Zinc finger protein 644

1

0

High-throughput

0.279

Low

1390355

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.279

Low

1390357

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

1390361

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.279

Low

1390362

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.279

Low

1390363

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.279

Low

1390364

TRPS1
Zinc finger transcription factor Trps1

1

0

High-throughput

0.279

Low

1390365

MCM8
DNA helicase MCM8

1

0

High-throughput

0.279

Low

1390367

TASOR
Protein TASOR

1

0

High-throughput

0.279

Low

1390370

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.279

Low

1390372

TTF2
Transcription termination factor 2

1

0

High-throughput

0.279

Low

1390375

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.279

Low

1004958

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025