HitPredict

Interactor 1: STX1A (P32851)
Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A)
Gene: STX1A

Interactor 2: STXB2 (Q62753)
Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Munc18-2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)
Gene: Stxbp2

Species: Rattus norvegicus

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	7768895
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin
Common GO terms	GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0006887 - exocytosis GO:0016079 - synaptic vesicle exocytosis GO:0032991 - protein-containing complex and 1 others more... GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Rn			1 594
+	Mm
		192851 STX1A_MOUSE (1-288): 4.85e-84: 255: 99.65		STXB2_MOUSE (1-594): 0: 696: 97.81
+	Hs
		699262 STX2_HUMAN (1-288): 5.02e-80: 245: 64.93		STXB2_HUMAN (1-594): 0: 689: 94.61
+	Rn
		838510 STX2_RAT (1-266): 6.69e-73: 227: 65.92		STXB2_RAT (1-594): 0: 693: 100.00
+	Mm
		139528 STX1A_MOUSE (1-288): 4.85e-84: 255: 99.65		STXB1_MOUSE (1-592): 0: 619: 62.86
+	Rn
		699173 STX1A_RAT (1-288): 6.8e-84: 255: 100.00		STXB1_RAT (1-592): 0: 619: 62.86
+	Mm
		139543 STX1B_MOUSE (1-288): 2.15e-83: 254: 83.68		STXB1_MOUSE (1-592): 0: 619: 62.86
+	Bt
		699167 STX1A_BOVIN (1-288): 1.29e-83: 254: 97.92		STXB1_BOVIN (1-592): 0: 619: 62.86
+	Rn
		898824 STX1B_RAT (1-288): 2.15e-83: 254: 83.68		STXB1_RAT (1-592): 0: 619: 62.86
+	Hs
		898829 STX1B_HUMAN (1-288): 2.15e-83: 254: 83.68		STXB1_HUMAN (1-592): 0: 619: 62.86
+	Hs
		901790 STX1A_HUMAN (1-287): 5.88e-82: 250: 98.96		STXB1_HUMAN (1-592): 0: 619: 62.86
+	Hs
		699253 STX2_HUMAN (1-288): 5.02e-80: 245: 64.93		STXB1_HUMAN (1-592): 0: 619: 62.86
+	Rn
		838509 STX2_RAT (1-266): 6.69e-73: 227: 65.92		STXB1_RAT (1-592): 0: 619: 62.86
+	Hs
		901776 STX4_HUMAN (1-287): 2.08e-63: 203: 43.92		STXB1_HUMAN (1-592): 0: 619: 62.86
+	Dm
		991124 STX1A_DROME (2-287): 5.63e-74: 229: 68.40		ROP_DROME (4-588): 0: 589: 53.58
+	Hs
		119613 STX2_HUMAN (1-288): 5.02e-80: 245: 64.93		STXB3_HUMAN (1-593): 0: 566: 45.06
+	Ce
		183451 STX1A_CAEEL (2-283): 1.3e-72: 226: 64.66		UNC18_CAEEL (4-589): 0: 573: 52.53
+	Hs
		119633 STX4_HUMAN (1-287): 2.08e-63: 203: 43.92		STXB3_HUMAN (1-593): 0: 566: 45.06
+	Dm
		1096639 STX1A_DROME (2-287): 5.63e-74: 229: 68.40		SLY1_DROME (7-589): 6.66e-138: 417: 17.43
+	Hs
		1017818 STX4_HUMAN (1-287): 2.08e-63: 203: 43.92		VPS45_HUMAN (13-581): 1.35e-146: 437: 20.65
+	Hs
		1017732 STX4_HUMAN (1-287): 2.08e-63: 203: 43.92		SCFD1_HUMAN (7-587): 1.99e-132: 403: 17.64