HitPredict

Interactor 1: KPR1 (P32895)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1)
Gene: PRS1

Interactor 2: KPR2 (P38620)
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 2)
Gene: PRS2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 11283351, 10212224, 30649305, 18467557
Identification Methods two hybrid pooling approach, two hybrid, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 427
Sc

1 318
+ Sc
+ Sc
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024