HitPredict

Interactor 1: A0A087WW66 (A0A087WW66)
26S proteasome non-ATPase regulatory subunit 1
Gene: PSMD1

Interactor 2: PRS10 (P62333)
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
Gene: PSMC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 914 Hs			1 389
+	Hs
		913340 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00
+	Hs
		906907 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42
+	Hs
		700 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00
+	Hs
		693 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68
+	Hs
		907132 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00
+	Hs
		798739 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68
+	Hs
		692 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65
+	Hs
		730338 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65
+	Dm
		1359019 PSMD1_DROME (2-894): 0: 1056: 58.84		Q9W414_DROME (5-389): 1.73e-131: 384: 89.35
+	Dm
		186132 PSMD1_DROME (2-894): 0: 1056: 58.84		PRS8_DROME (5-387): 4.86e-126: 370: 47.00
+	Dm
		1359001 PSMD1_DROME (2-894): 0: 1056: 58.84		Q9V405_DROME (6-383): 4.92e-120: 355: 40.74
+	Dm
		1181026 PSMD1_DROME (2-894): 0: 1056: 58.84		Q7KMQ0_DROME (66-377): 2.33e-103: 313: 49.36
+	Sc
		693337 RPN2_YEAST (2-914): 0: 919: 38.04		PRS10_YEAST (3-389): 2.22e-122: 362: 67.70
+	Sc
		693349 RPN2_YEAST (2-914): 0: 919: 38.04		PRS8_YEAST (10-387): 8.63e-117: 347: 43.92
+	Sc
		693271 RPN2_YEAST (2-914): 0: 919: 38.04		PRS7_YEAST (68-386): 2.09e-103: 315: 48.75
+	Hs
		906819 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42
+	Hs
		907011 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00
+	Hs
		66339 PSMD2_HUMAN (8-712): 0: 704: 20.00		A8K2M0_HUMAN (3-383): 3.42e-121: 359: 40.68
+	Hs
		798648 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68
+	Hs
		730247 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65