Protein: PSME1
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)

Gene: PSME1
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q06323

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008537 - proteasome activator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054667

PSME2
Proteasome activator complex subunit 2

17

4

Small-scale

0.985

High

680849

PSA1
Proteasome subunit alpha type-1

8

16

Small-scale

0.967

High

1054636

PSB7
Proteasome subunit beta type-7

6

20

Small-scale

0.945

High

1054573

PSME1
Proteasome activator complex subunit 1

6

4

Small-scale

0.943

High

700514

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.927

High

887644

PSB2
Proteasome subunit beta type-2

5

20

Small-scale

0.925

High

681152

PSA2
Proteasome subunit alpha type-2

5

18

Small-scale

0.922

High

700873

PSB4
Proteasome subunit beta type-4

4

20

High-throughput

0.895

High

700615

PSA5
Proteasome subunit alpha type-5

4

15

Small-scale

0.892

High

633665

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.871

High

887518

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.871

High

165314

PSA7
Proteasome subunit alpha type-7

3

16

Small-scale

0.861

High

681627

PSA4
Proteasome subunit alpha type-4

3

19

Small-scale

0.847

High

822140

PSB10
Proteasome subunit beta type-10

3

20

Small-scale

0.847

High

954795

PSA6
Proteasome subunit alpha type-6

3

18

Small-scale

0.847

High

701021

PSB6
Proteasome subunit beta type-6

2

20

Small-scale

0.789

High

681350

PSA3
Proteasome subunit alpha type-3

2

14

Small-scale

0.754

High

700455

PSB8
Proteasome subunit beta type-8

2

20

Small-scale

0.754

High

701139

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.691

High

138080

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

2

Small-scale

0.676

High

1054627

PSMG2
Proteasome assembly chaperone 2

3

2

High-throughput

0.675

High

933622

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

1

High-throughput

0.611

High

1054587

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

2

Small-scale

0.611

High

1054669

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

1054675

FBX7
F-box only protein 7

2

2

Small-scale

0.611

High

822196

CTRL
Chymotrypsin-like protease CTRL-1

3

1

High-throughput

0.609

High

187343

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

2

1

High-throughput

0.601

High

954680

SEM1
26S proteasome complex subunit SEM1

2

2

Small-scale

0.601

High

1054586

PSME4
Proteasome activator complex subunit 4

2

0

Small-scale

0.585

High

968890

PRS8
26S proteasome regulatory subunit 8

2

3

Small-scale

0.584

High

1054590

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

1

Small-scale

0.584

High

1054611

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

5

High-throughput

0.584

High

165038

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

0

High-throughput

0.576

High

1054594

INAVA
Innate immunity activator protein

2

0

High-throughput

0.576

High

114599

H0YKT8
Proteasome subunit beta

1

19

High-throughput

0.575

High

1054641

RNF26
E3 ubiquitin-protein ligase RNF26

2

2

High-throughput

0.558

High

529685

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.552

High

1054645

VPS11
Vacuolar protein sorting-associated protein 11 homolog

2

1

High-throughput

0.549

High

613341

VINC
Vinculin

1

1

High-throughput

0.541

High

899851

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

900287

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.541

High

923586

TTC3
E3 ubiquitin-protein ligase TTC3

1

2

High-throughput

0.541

High

1054575

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.541

High

210925

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

229138

GTPB6
Putative GTP-binding protein 6

1

1

High-throughput

0.536

High

786559

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.536

High

833619

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.536

High

851297

PRS6B
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.536

High

958561

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

1

High-throughput

0.536

High

1054605

TTLL5
Tubulin polyglutamylase TTLL5

1

1

High-throughput

0.536

High

1054633

NSUN5
28S rRNA

1

1

High-throughput

0.536

High

1054634

CDK15
Cyclin-dependent kinase 15

1

1

High-throughput

0.536

High

1054638

PSMG3
Proteasome assembly chaperone 3

1

1

High-throughput

0.536

High

1054639

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.536

High

1054648

CSR2B
Cysteine-rich protein 2-binding protein

1

2

High-throughput

0.536

High

1054652

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.536

High

1054654

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.536

High

1054659

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.536

High

1054668

YETS2
YEATS domain-containing protein 2

1

2

High-throughput

0.536

High

1054673

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

1

High-throughput

0.536

High

894699

EMD
Emerin

1

0

Small-scale

0.529

High

261795

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.518

High

474630

VIME
Vimentin

1

0

High-throughput

0.518

High

1054672

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.518

High

1054653

CXB4
Gap junction beta-4 protein

1

3

High-throughput

0.515

High

331747

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.513

High

885750

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.513

High

958936

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

981798

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

1054580

PEX6
Peroxisomal ATPase PEX6

1

0

High-throughput

0.513

High

1054613

DEN6A
Protein DENND6A

1

0

High-throughput

0.513

High

1054616

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

1054618

FBX30
F-box only protein 30

1

0

High-throughput

0.513

High

1054619

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.513

High

1054629

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

1054650

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

1054656

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

1054657

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.513

High

1054660

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

1054661

DUX4
Double homeobox protein 4

1

0

High-throughput

0.513

High

1054664

TASOR
Protein TASOR

1

0

High-throughput

0.513

High

1054665

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

1054671

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

1054678

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

1054625

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

1

High-throughput

0.508

High

421976

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

442303

GELS
Gelsolin

1

0

High-throughput

0.493

High

1054599

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.493

High

1054670

UBQL1
Ubiquilin-1

1

0

High-throughput

0.493

High

870713

CXA8
Gap junction alpha-8 protein

1

3

High-throughput

0.489

High

1054584

DIP2A
Disco-interacting protein 2 homolog A

1

1

High-throughput

0.489

High

1054600

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

1

High-throughput

0.489

High

1054614

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.489

High

1054649

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.489

High

325432

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

405441

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

420787

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.486

High

1054578

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.486

High

1054589

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.486

High

1054591

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

1054592

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

997296

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.481

High

127938

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

Small-scale

0.479

High

131978

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

241479

PRKN
E3 ubiquitin-protein ligase parkin

1

2

Small-scale

0.479

High

259842

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

315496

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

347659

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

371842

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

588532

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

599196

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

606675

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

610307

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

651294

CBL
E3 ubiquitin-protein ligase CBL

1

2

High-throughput

0.479

High

685519

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.479

High

695281

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

772759

MYH9
Myosin-9

1

2

High-throughput

0.479

High

773165

MYH10
Myosin-10

1

2

High-throughput

0.479

High

773731

ACTN2
Alpha-actinin-2

1

2

High-throughput

0.479

High

776806

MYH11
Myosin-11

1

2

High-throughput

0.479

High

851751

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

887999

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

964878

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

968689

PRS4
26S proteasome regulatory subunit 4

1

3

Small-scale

0.479

High

970384

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1054574

ACTN3
Alpha-actinin-3

1

2

High-throughput

0.479

High

1054581

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1054588

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1054593

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.479

High

1054597

AKIR2
Akirin-2

1

1

Small-scale

0.479

High

1054601

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

1054604

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1054608

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1054612

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

Small-scale

0.479

High

1054620

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.479

High

1054623

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1054632

SCLT1
Sodium channel and clathrin linker 1

1

5

High-throughput

0.479

High

1054637

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1054644

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

1054646

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1054647

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.479

High

1054658

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1054662

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1054676

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

4

Small-scale

0.479

High

650137

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.470

High

941142

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

320666

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

903063

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.458

High

987570

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.458

High

1054576

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.458

High

1054577

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

1054609

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.458

High

1054582

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.457

High

140237

SDCB1
Syntenin-1

1

1

High-throughput

0.445

High

563669

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1054603

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

1054621

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

2

High-throughput

0.445

High

1054628

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.445

High

1054642

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1054579

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

1054626

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.438

High

1054651

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

353276

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

1054617

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.437

High

1054666

GPTC8
G patch domain-containing protein 8

1

3

High-throughput

0.437

High

1054674

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

327582

ELP1
Elongator complex protein 1

1

0

High-throughput

0.426

High

1034434

TAGL
Transgelin

1

0

High-throughput

0.426

High

1054596

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1054606

ELP2
Elongator complex protein 2

1

0

High-throughput

0.426

High

1054610

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.426

High

886788

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

701

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.407

High

97077

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.407

High

1054663

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.407

High

416014

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

1054631

DOCK7
Dedicator of cytokinesis protein 7

2

0

High-throughput

0.313

High

560374

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.279

Low

1012680

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.279

Low

1054583

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.279

Low

1054595

ACSF4
Beta-alanine-activating enzyme

1

0

High-throughput

0.279

Low

1054615

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1054624

FIG4
Polyphosphoinositide phosphatase

1

0

High-throughput

0.279

Low

1054630

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1054635

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

1054640

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

1054655

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.279

Low

1054585

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

1054622

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1054677

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1054598

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1054602

ERI6B
Glutamate-rich protein 6B

1

0

High-throughput

0.249

Low

1017770

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

1054607

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.232

Low

1054643

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025