HitPredict

Interactor 1: CADH5 (P33151)
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Gene: CDH5

Interactor 2: PTPRU (Q92729)
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)
Gene: PTPRU

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0008013 - beta-catenin binding GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 784 Hs			1 1446
+	Hs
		1269196 PCDB3_HUMAN (55-674): 3.43e-117: 374: 20.18		PTPRU_HUMAN (1-1446): 0: 1131: 100.00
+	Hs
		1269195 PCDB7_HUMAN (1-492): 2.07e-91: 305: 21.54		PTPRU_HUMAN (1-1446): 0: 1131: 100.00
+	Hs
		521728 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRG_HUMAN (295-1445): 0: 670: 21.71
+	Hs
		521898 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRJ_HUMAN (216-1444): 1.65e-118: 405: 14.03
+	Hs
		576981 CADH2_HUMAN (1-469): 4.36e-61: 224: 20.67		PTPRA_HUMAN (673-1443): 0: 755: 28.46
+	Hs
		616903 CADH5_HUMAN (1-784): 0: 794: 100.00		PTPRB_HUMAN (2-813): 4.3e-10: 66.9: 10.42
+	Mm
		472763 CADH5_MOUSE (1-783): 0: 750: 74.68		PTPRQ_MOUSE (334-901): 6.58e-21: 102: 11.33
+	Hs
		489891 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64
+	Mm
		70734 CADH5_MOUSE (1-783): 0: 750: 74.68		PTPRB_MOUSE (241-943): 2.23e-11: 71.1: 11.20
+	Hs
		521743 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRM_HUMAN (903-1148): 2.37e-49: 195: 28.85
+	Mm
		454946 CADH1_MOUSE (25-780): 0: 582: 30.99		PTPRM_MOUSE (903-1148): 7.04e-50: 196: 28.85
+	Hs
		521727 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRD_HUMAN (187-963): 3.95e-39: 162: 10.28
+	Hs
		521907 CADH1_HUMAN (26-780): 0: 590: 31.71		PTPRS_HUMAN (187-943): 1.73e-38: 160: 10.32
+	Mm
		454937 CADH1_MOUSE (25-780): 0: 582: 30.99		PTPRQ_MOUSE (334-901): 6.58e-21: 102: 11.33
+	Hs
		490028 PCDBG_HUMAN (1-492): 5.01e-94: 312: 20.93		PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64
+	Rn
		1145482 CADH2_RAT (1-469): 8.57e-62: 225: 20.83		PTPRF_RAT (4-795): 3.51e-70: 262: 13.50
+	Hs
		617023 PCDBG_HUMAN (1-492): 5.01e-94: 312: 20.93		PTPRD_HUMAN (187-963): 3.95e-39: 162: 10.28
+	Hs
		441173 CADH2_HUMAN (1-469): 4.36e-61: 224: 20.67		PTPRC_HUMAN (879-1156): 7.53e-63: 238: 26.92
+	Rn
		94056 CADH2_RAT (1-469): 8.57e-62: 225: 20.83		F1LPJ1_RAT (903-1148): 8.8e-50: 196: 28.85
+	Mm
		472760 CADH2_MOUSE (1-469): 3.89e-62: 227: 20.83		PTPRQ_MOUSE (334-901): 6.58e-21: 102: 11.33