HitPredict

Interactor 1: PRS6B (P33298)
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)
Gene: RPT3

Interactor 2: UBP6 (P43593)
Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)
Gene: UBP6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	11805826, 37968396, 16554755, 16429126, 22940862, 14759368
Identification Methods	tandem affinity purification, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Prot_ATP_ID_OB~UCH
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 428 Sc			1 499
+	Sp
		252275 PRS6B_SCHPO (40-428): 1.77e-119: 354: 77.89		UBP6_SCHPO (5-499): 1.89e-113: 345: 37.02
+	Hs
		870728 PRS4_HUMAN (15-427): 5.03e-128: 378: 44.34		UBP14_HUMAN (5-499): 1.27e-103: 320: 29.12
+	Sc
		771716 PRS4_YEAST (49-410): 4.56e-110: 332: 47.53		UBP6_YEAST (1-495): 9.09e-119: 359: 100.00
+	Hs
		798619 PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57		UBP14_HUMAN (5-499): 1.27e-103: 320: 29.12
+	Sp
		736969 PRS4_SCHPO (49-419): 7.63e-113: 340: 49.33		UBP6_SCHPO (5-499): 1.89e-113: 345: 37.02
+	Hs
		870733 PRS10_HUMAN (41-426): 2.56e-123: 364: 37.57		UBP14_HUMAN (5-499): 1.27e-103: 320: 29.12
+	Hs
		870729 PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59		UBP14_HUMAN (5-499): 1.27e-103: 320: 29.12
+	Hs
		907177 PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59		UBP36_HUMAN (3-496): 3.71e-76: 261: 14.46
+	Dm
		186175 PRS8_DROME (32-423): 7.65e-123: 364: 40.05		X2JLM6_DROME (65-496): 7.48e-76: 250: 15.51
+	Hs
		798616 PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57		UBP11_HUMAN (325-499): 1.73e-30: 127: 18.64