Protein: COS8
Protein COS8

Gene: COS8
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P38723

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0005635 - nuclear envelope
GO:0016020 - membrane
GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577120

SEC63
Protein translocation protein SEC63

2

1

Small-scale

0.559

High

663601

VATO
V-type proton ATPase subunit c''

1

2

High-throughput

0.541

High

678544

YCV1
Uncharacterized membrane protein YCR061W

1

1

High-throughput

0.541

High

796911

PHO88
SRP-independent targeting protein 3

1

5

High-throughput

0.541

High

802991

MST28
Multicopy suppressor of SEC21 protein 28

1

13

High-throughput

0.541

High

802992

SHO1
High osmolarity signaling protein SHO1

1

2

High-throughput

0.541

High

802994

SNL1
HSP70 co-chaperone SNL1

1

3

High-throughput

0.541

High

802997

PRM10
Pheromone-regulated membrane protein 10

1

1

High-throughput

0.541

High

802998

PHO86
Inorganic phosphate transporter PHO86

1

2

High-throughput

0.541

High

803003

MAL11
General alpha-glucoside permease

1

6

High-throughput

0.541

High

803004

MST27
Multicopy suppressor of SEC21 protein 27

1

13

High-throughput

0.541

High

803011

FMP42
Protein FMP42

1

2

High-throughput

0.541

High

803013

AMF1
Low affinity ammonium transporter

1

14

High-throughput

0.541

High

803015

YOP1
Protein YOP1

1

1

High-throughput

0.541

High

803016

ERP4
Protein ERP4

1

3

High-throughput

0.541

High

780445

SRPB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.518

High

803000

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.518

High

506368

NFT1
ABC transporter NFT1

1

1

High-throughput

0.494

High

528583

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

High-throughput

0.494

High

609274

CPT1
Cholinephosphotransferase 1

1

2

High-throughput

0.494

High

672797

ELO2
Fatty acid elongase 2

1

10

High-throughput

0.494

High

703815

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.494

High

776356

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.494

High

781296

AUR1
Inositol phosphorylceramide synthase catalytic subunit AUR1

1

2

High-throughput

0.494

High

797380

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

7

High-throughput

0.494

High

799700

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

2

High-throughput

0.494

High

802475

LAG1
Ceramide synthase LAG1

1

1

High-throughput

0.494

High

802988

YHU0
UPF0641 membrane protein YHR140W

1

2

High-throughput

0.494

High

802990

ELO1
Fatty acid elongase 1

1

10

High-throughput

0.494

High

802993

ELO3
Fatty acid elongase 3

1

10

High-throughput

0.494

High

802995

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.494

High

802999

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

3

High-throughput

0.494

High

803001

STE24
CAAX prenyl protease 1

1

1

High-throughput

0.494

High

803005

ERV29
ER-derived vesicles protein ERV29

1

1

High-throughput

0.494

High

803007

RT23
Small ribosomal subunit protein mS29

1

2

High-throughput

0.494

High

803008

SHR3
Secretory component protein SHR3

1

3

High-throughput

0.494

High

803009

PDR12
ATP-dependent permease PDR12

1

3

High-throughput

0.494

High

803010

GSF2
Glucose-signaling factor 2

1

3

High-throughput

0.494

High

803012

TPO3
Polyamine transporter 3

1

15

High-throughput

0.494

High

94515

YAJ3
Putative DUP240 protein DFP1

1

13

High-throughput

0.481

High

506392

YK104
Putative uncharacterized protein YKR104W

1

1

High-throughput

0.481

High

506201

AQY1
Aquaporin-1

1

2

High-throughput

0.439

High

803006

ARE2
Sterol O-acyltransferase 2

1

1

Small-scale

0.439

High

544743

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.407

High

598507

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.282

High

694199

BUD14
Bud site selection protein 14

1

0

High-throughput

0.282

High

782612

TVP38
Golgi apparatus membrane protein TVP38

1

0

High-throughput

0.282

High

797593

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.282

High

802989

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.282

High

802996

SSU1
Sulfite efflux pump SSU1

1

0

High-throughput

0.282

High

803014

PFA4
Palmitoyltransferase PFA4

1

0

High-throughput

0.282

High

803017

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.282

High

803002

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025