HitPredict

Interactor 1: PRS7 (P33299)
26S proteasome regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3)
Gene: RPT1

Interactor 2: PSA4 (P40303)
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)
Gene: PRE6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	37968396, 16429126, 22307589
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Sc			1 254
+	Hs
		156240 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01
+	Dm
		1278638 Q9V405_DROME (60-459): 2.26e-135: 397: 35.50		PSA5_DROME (2-237): 3.02e-91: 270: 31.28
+	Dm
		611655 Q9V405_DROME (60-459): 2.26e-135: 397: 35.50		PSA71_DROME (2-233): 1.09e-88: 264: 51.72
+	Hs
		638074 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49
+	Hs
		730228 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75
+	Hs
		637341 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35
+	Hs
		656158 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92
+	Sc
		771373 PRS10_YEAST (29-465): 2.46e-123: 367: 37.07		PSA4_YEAST (1-254): 1.72e-97: 287: 100.00
+	Sp
		194877 PRS7_SCHPO (1-465): 1.02e-126: 376: 73.33		PSA4_SCHPO (1-252): 1.7e-93: 277: 55.95
+	Dm
		1181022 Q7KMQ0_DROME (12-467): 4.56e-129: 382: 68.64		PSA5_DROME (2-237): 3.02e-91: 270: 31.28
+	Sp
		194879 PRS7_SCHPO (1-465): 1.02e-126: 376: 73.33		PSA5_SCHPO (2-239): 2.2e-93: 276: 36.48
+	Dm
		611645 Q7KMQ0_DROME (12-467): 4.56e-129: 382: 68.64		PSA71_DROME (2-233): 1.09e-88: 264: 51.72
+	Dm
		611676 Q9W414_DROME (79-463): 7.34e-124: 367: 43.90		PSA71_DROME (2-233): 1.09e-88: 264: 51.72
+	Dm
		771310 Q9V405_DROME (60-459): 2.26e-135: 397: 35.50		PSA2_DROME (4-214): 9.25e-44: 149: 40.28
+	Sc
		619347 PRS7_YEAST (1-467): 2.69e-137: 405: 100.00		PSA3_YEAST (4-207): 3.34e-40: 140: 35.29
+	Hs
		637639 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14
+	Dm
		771298 Q7KMQ0_DROME (12-467): 4.56e-129: 382: 68.64		PSA2_DROME (4-214): 9.25e-44: 149: 40.28
+	Dm
		771301 Q8SZ19_DROME (79-463): 9.85e-124: 367: 43.64		PSA2_DROME (4-214): 9.25e-44: 149: 40.28
+	Dm
		771327 Q9W414_DROME (79-463): 7.34e-124: 367: 43.90		PSA2_DROME (4-214): 9.25e-44: 149: 40.28
+	Sc
		619375 PRS10_YEAST (29-465): 2.46e-123: 367: 37.07		PSA3_YEAST (4-207): 3.34e-40: 140: 35.29