Protein: CLK2
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)

Gene: CLK2
Organism: Homo sapiens
Interactions: 207
UniProt ID: P49760

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889537

CLK3
Dual specificity protein kinase CLK3

8

17

High-throughput

0.975

High

889616

SNIP1
Smad nuclear-interacting protein 1

8

2

High-throughput

0.975

High

472532

RU17
U1 small nuclear ribonucleoprotein 70 kDa

5

15

High-throughput

0.935

High

889375

CLK1
Dual specificity protein kinase CLK1

5

17

High-throughput

0.927

High

889536

CLK2
Dual specificity protein kinase CLK2

5

16

Small-scale

0.924

High

889567

RBM39
RNA-binding protein 39

4

20

High-throughput

0.909

High

889573

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

4

3

High-throughput

0.904

High

889571

RNPS1
RNA-binding protein with serine-rich domain 1

4

15

High-throughput

0.895

High

889619

ZN398
Zinc finger protein 398

3

5

High-throughput

0.871

High

284095

SRS10
Serine/arginine-rich splicing factor 10

3

20

Small-scale

0.866

High

889645

SRSF8
Serine/arginine-rich splicing factor 8

3

14

High-throughput

0.863

High

889564

TRA2A
Transformer-2 protein homolog alpha

3

20

High-throughput

0.861

High

889552

SRSF3
Serine/arginine-rich splicing factor 3

3

20

High-throughput

0.858

High

889550

SRPK2
SRSF protein kinase 2

2

18

High-throughput

0.817

High

889611

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

8

High-throughput

0.817

High

889563

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

18

High-throughput

0.811

High

889568

ZN638
Zinc finger protein 638

2

11

High-throughput

0.811

High

889625

SRS12
Serine/arginine-rich splicing factor 12

2

20

High-throughput

0.811

High

889650

REPI1
DNA-binding protein REPIN1

2

2

High-throughput

0.811

High

889557

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.799

High

461273

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

302431

RNF8
E3 ubiquitin-protein ligase RNF8

2

8

High-throughput

0.783

High

889541

ZN136
Zinc finger protein 136

2

6

High-throughput

0.783

High

889608

ZN440
Zinc finger protein 440

2

6

High-throughput

0.783

High

889613

ZN491
Zinc finger protein 491

2

6

High-throughput

0.783

High

889635

ZN837
Zinc finger protein 837

2

2

High-throughput

0.783

High

889636

ZN764
Zinc finger protein 764

2

3

High-throughput

0.783

High

889640

ZN558
Zinc finger protein 558

2

5

High-throughput

0.783

High

889641

ZN317
Zinc finger protein 317

2

2

High-throughput

0.783

High

889658

ZN436
Zinc finger protein 436

2

2

High-throughput

0.783

High

889662

ZN768
Zinc finger protein 768

2

1

High-throughput

0.783

High

889687

ZSC21
Zinc finger and SCAN domain-containing protein 21

2

1

High-throughput

0.783

High

728114

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.747

High

171848

ZN263
Zinc finger protein 263

1

3

High-throughput

0.740

High

889553

U2AF1
Splicing factor U2AF 35 kDa subunit

1

3

High-throughput

0.740

High

889580

ZN394
Zinc finger protein 394

1

6

High-throughput

0.740

High

889621

ZN473
Zinc finger protein 473

1

2

High-throughput

0.740

High

889648

RSRP1
Arginine/serine-rich protein 1

6

1

High-throughput

0.738

High

889561

ELAV2
ELAV-like protein 2

2

15

High-throughput

0.726

High

889634

RMXL1
RNA binding motif protein, X-linked-like-1

2

20

High-throughput

0.726

High

889639

YTDC1
YTH domain-containing protein 1

5

6

High-throughput

0.725

High

889668

BCLF1
Bcl-2-associated transcription factor 1

4

15

High-throughput

0.704

High

889598

RBBP6
E3 ubiquitin-protein ligase RBBP6

4

11

High-throughput

0.699

High

889660

PININ
Pinin

4

3

High-throughput

0.699

High

889678

ACINU
Apoptotic chromatin condensation inducer in the nucleus

4

18

High-throughput

0.699

High

889609

CLASR
CLK4-associating serine/arginine rich protein

4

9

High-throughput

0.698

High

251542

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

256595

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

20

High-throughput

0.691

High

462299

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.691

High

477952

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.691

High

550181

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.691

High

600528

ZNF30
Zinc finger protein 30

1

1

High-throughput

0.691

High

685451

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.691

High

701776

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.691

High

876774

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.691

High

889538

RGS3
Regulator of G-protein signaling 3

1

3

High-throughput

0.691

High

889539

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

10

High-throughput

0.691

High

889544

TRA2B
Transformer-2 protein homolog beta

1

20

High-throughput

0.691

High

889547

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.691

High

889548

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.691

High

889556

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

889558

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

889560

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

High-throughput

0.691

High

889562

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

889572

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

17

High-throughput

0.691

High

889574

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.691

High

889575

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

14

High-throughput

0.691

High

889578

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

889628

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

17

High-throughput

0.691

High

889633

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.691

High

889680

SRPK3
SRSF protein kinase 3

1

17

High-throughput

0.691

High

889686

RBM7
RNA-binding protein 7

1

16

High-throughput

0.691

High

889543

1433G
14-3-3 protein gamma

4

20

High-throughput

0.687

High

889605

SRRM1
Serine/arginine repetitive matrix protein 1

3

16

High-throughput

0.685

High

889615

PPHLN
Periphilin-1

3

2

High-throughput

0.675

High

889655

SETD2
Histone-lysine N-methyltransferase SETD2

3

4

High-throughput

0.675

High

889659

WDR33
pre-mRNA 3' end processing protein WDR33

3

13

High-throughput

0.675

High

889542

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.667

High

889684

TR150
Thyroid hormone receptor-associated protein 3

3

20

High-throughput

0.667

High

889685

LC7L2
Putative RNA-binding protein Luc7-like 2

3

7

High-throughput

0.667

High

92337

D3DU92
RNA-binding protein with serine-rich domain 1

1

15

High-throughput

0.665

High

889665

LUC7L
Putative RNA-binding protein Luc7-like 1

5

6

High-throughput

0.656

High

889617

LNX1
E3 ubiquitin-protein ligase LNX

5

8

High-throughput

0.654

High

690831

1433T
14-3-3 protein theta

3

20

Small-scale

0.650

High

729682

1433B
14-3-3 protein beta/alpha

3

20

Small-scale

0.650

High

889657

UBL5
Ubiquitin-like protein 5

1

3

Small-scale

0.647

High

889669

LUZP4
Leucine zipper protein 4

3

0

High-throughput

0.646

High

889589

ZCHC8
Zinc finger CCHC domain-containing protein 8

3

0

High-throughput

0.646

High

571902

TRI27
Zinc finger protein RFP

2

5

High-throughput

0.644

High

889614

PR38A
Pre-mRNA-splicing factor 38A

2

1

High-throughput

0.633

High

183437

CASC3
Protein CASC3

2

6

High-throughput

0.628

High

217408

E41L2
Band 4.1-like protein 2

2

5

High-throughput

0.628

High

615349

SON
Protein SON

2

15

High-throughput

0.628

High

719525

NKTR
NK-tumor recognition protein

2

6

High-throughput

0.628

High

868340

CDX1
Homeobox protein CDX-1

2

6

High-throughput

0.628

High

889590

RSBNL
Lysine-specific demethylase RSBN1L

2

1

High-throughput

0.628

High

889591

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

1

High-throughput

0.628

High

889601

ZCH18
Zinc finger CCCH domain-containing protein 18

2

18

High-throughput

0.628

High

889652

SRRT
Serrate RNA effector molecule homolog

2

2

High-throughput

0.628

High

889663

NCOA5
Nuclear receptor coactivator 5

2

1

High-throughput

0.628

High

889677

GPTC8
G patch domain-containing protein 8

2

10

High-throughput

0.628

High

889681

SRRM2
Serine/arginine repetitive matrix protein 2

2

20

High-throughput

0.628

High

889688

TNPO3
Transportin-3

2

11

High-throughput

0.628

High

889610

FGRL1
Fibroblast growth factor receptor-like 1

1

9

High-throughput

0.618

High

889644

CAB45
45 kDa calcium-binding protein

1

5

High-throughput

0.618

High

468182

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

889540

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

High-throughput

0.618

High

329047

KLHL2
Kelch-like protein 2

3

1

High-throughput

0.616

High

844180

ECE1
Endothelin-converting enzyme 1

3

1

High-throughput

0.616

High

321464

PRP6
Pre-mRNA-processing factor 6

2

8

High-throughput

0.614

High

889595

Q7KZS0
SUMO-conjugating enzyme UBC9

2

8

High-throughput

0.611

High

889672

NXF1
Nuclear RNA export factor 1

2

2

High-throughput

0.606

High

889546

UBC9
SUMO-conjugating enzyme UBC9

2

8

High-throughput

0.584

High

410468

HSP1
Sperm protamine P1

2

0

High-throughput

0.580

High

889622

CATIN
Splicing factor Cactin

2

0

High-throughput

0.580

High

889656

ASPC1
Tether containing UBX domain for GLUT4

2

0

High-throughput

0.580

High

889594

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

889606

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

4

High-throughput

0.574

High

140182

SDCB1
Syntenin-1

1

7

High-throughput

0.573

High

889602

TRI50
E3 ubiquitin-protein ligase TRIM50

2

5

High-throughput

0.553

High

889632

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

889651

GTPB2
GTP-binding protein 2

2

7

High-throughput

0.553

High

889626

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.553

High

798848

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.552

High

889555

1433F
14-3-3 protein eta

2

20

High-throughput

0.549

High

134609

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.536

High

192562

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

209222

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

12

High-throughput

0.536

High

272902

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

330430

LC7L3
Luc7-like protein 3

1

6

High-throughput

0.536

High

340734

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

6

High-throughput

0.536

High

838680

MTREX
Exosome RNA helicase MTR4

1

11

High-throughput

0.536

High

889576

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

15

High-throughput

0.536

High

889577

RN151
RING finger protein 151

1

16

High-throughput

0.536

High

889593

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.536

High

889596

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

889599

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.536

High

889603

DHX40
Probable ATP-dependent RNA helicase DHX40

1

8

High-throughput

0.536

High

889629

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

High-throughput

0.536

High

889642

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.536

High

889643

PKP2
Plakophilin-2

1

14

High-throughput

0.536

High

889673

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

889674

TRM7
tRNA

1

1

High-throughput

0.536

High

889676

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

611033

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

Small-scale

0.519

High

889584

CE170
Centrosomal protein of 170 kDa

1

16

High-throughput

0.514

High

889565

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

889579

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.513

High

889670

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

0

High-throughput

0.513

High

889671

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

889689

TX264
Testis-expressed protein 264

1

0

High-throughput

0.513

High

889592

LARP1
La-related protein 1

1

16

High-throughput

0.489

High

889627

LAR4B
La-related protein 4B

1

14

High-throughput

0.489

High

889638

JPH4
Junctophilin-4

1

1

High-throughput

0.489

High

889661

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.489

High

889664

WDR6
tRNA

1

20

High-throughput

0.489

High

889679

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.489

High

889683

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.489

High

334281

TACC2
Transforming acidic coiled-coil-containing protein 2

1

12

High-throughput

0.481

High

889549

RBM6
RNA-binding protein 6

1

15

High-throughput

0.481

High

889585

RM02
Large ribosomal subunit protein uL2m

1

3

High-throughput

0.481

High

889600

PATL1
Protein PAT1 homolog 1

1

9

High-throughput

0.481

High

889637

GMCL1
Germ cell-less protein-like 1

1

4

High-throughput

0.481

High

285143

EED
Polycomb protein EED

1

17

High-throughput

0.479

High

342794

HERC2
E3 ubiquitin-protein ligase HERC2

1

13

High-throughput

0.479

High

704726

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

744640

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.479

High

842688

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

9

High-throughput

0.479

High

878777

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

889545

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

4

High-throughput

0.479

High

889554

ENL
Protein ENL

1

13

High-throughput

0.479

High

889566

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

889582

Q59FZ7
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

889597

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

889607

FANCM
Fanconi anemia group M protein

1

15

Small-scale

0.479

High

889623

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

889649

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

889666

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

889675

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

74234

B2RWP4
TACC2 protein

1

19

High-throughput

0.470

High

889559

ECHP
Peroxisomal bifunctional enzyme

1

2

High-throughput

0.470

High

889581

Q53SE7
Germ cell-less homolog 1

1

4

High-throughput

0.470

High

889624

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.460

High

889682

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.460

High

889569

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

889570

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

889612

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

889647

FAP24
Fanconi anemia core complex-associated protein 24

1

0

Small-scale

0.458

High

3424

A0A0S2Z4Z6
Serine/arginine repetitive matrix protein 1

1

19

High-throughput

0.457

High

608501

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.445

High

765255

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

889583

ODFP2
Outer dense fiber protein 2

1

17

High-throughput

0.445

High

889630

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

4

High-throughput

0.445

High

889631

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.439

High

889654

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.439

High

889667

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.439

High

889586

TBC9B
TBC1 domain family member 9B

1

3

High-throughput

0.437

High

889587

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

889588

Q6ICH2
single-stranded DNA cytosine deaminase

1

4

High-throughput

0.437

High

889646

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

640577

MK
Midkine

2

0

High-throughput

0.328

High

889604

GPAM1
GPALPP motifs-containing protein 1

2

0

High-throughput

0.328

High

889653

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.299

High

889551

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

889618

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

889620

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025