HitPredict

Interactor 1: PRP8 (P33334)
Pre-mRNA-splicing factor 8
Gene: PRP8

Interactor 2: LSM8 (P47093)
U6 snRNA-associated Sm-like protein LSm8
Gene: LSM8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	10747033, 23560879, 16373487, 37968396, 16429126
Identification Methods	biochemical, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~PRP8_domainIV
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005737 - cytoplasm and 1 others more... GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2413 Sc			1 109
+	Hs
		321409 PRP8_HUMAN (52-2413): 0: 4464: 61.34		LSM8_HUMAN (1-85): 1.33e-29: 103: 27.47
+	Hs
		912060 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RUXG_HUMAN (3-69): 6.78e-25: 90.8: 20.29
+	Hs
		68429 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RUXGL_HUMAN (3-69): 6.48e-23: 85.8: 20.29
+	Hs
		1159329 PRP8_HUMAN (52-2413): 0: 4464: 61.34		LSM7_HUMAN (5-81): 4.87e-19: 77: 17.24
+	Hs
		927976 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RSMN_HUMAN (2-64): 5.94e-17: 74.7: 20.00
+	Hs
		539013 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RSMB_HUMAN (2-64): 9.82e-17: 74.3: 20.00
+	Sc
		704677 PRP8_YEAST (1-2413): 0: 4084: 100.00		RUXG_YEAST (2-69): 1.63e-17: 72.4: 21.62
+	Sc
		704696 PRP8_YEAST (1-2413): 0: 4084: 100.00		LSM7_YEAST (5-71): 3.29e-13: 62.3: 15.00
+	Sc
		704699 PRP8_YEAST (1-2413): 0: 4084: 100.00		LSM3_YEAST (5-76): 5.4e-10: 53.5: 22.22