HitPredict

Interactor 1: GCYA2 (P33402)
Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)
Gene: GUCY1A2

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	11572861, 30126976
Identification Methods	affinity chromatography technology, p8 filamentous phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 724
+	Rn
		677808 GCYA2_RAT (1-732): 0: 906: 90.98		DLG4_RAT (1-724): 0: 668: 99.86
+	Rn
		594291 GCYB1_RAT (112-703): 0: 646: 33.87		DLG4_RAT (1-724): 0: 668: 99.86
+	Rn
		1144018 GCYA2_RAT (1-732): 0: 906: 90.98		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Rn
		1144362 GCYA2_RAT (1-732): 0: 906: 90.98		DLG2_RAT (225-474): 1.48e-18: 92.5: 21.09
+	Rn
		1144082 GCYA2_RAT (1-732): 0: 906: 90.98		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55
+	Hs
		704963 GCYA2_HUMAN (1-732): 0: 864: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		704960 GCYA2_HUMAN (1-732): 0: 864: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		704964 GCYA2_HUMAN (1-732): 0: 864: 100.00		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		704965 GCYA2_HUMAN (1-732): 0: 864: 100.00		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58