Protein: RBL2
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)

Gene: RBL2
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q08999

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667808

CDK2
Cyclin-dependent kinase 2

13

9

Small-scale

0.761

High

1065666

E2F4
Transcription factor E2F4

13

20

Small-scale

0.758

High

704949

RBL1
Retinoblastoma-like protein 1

2

2

Small-scale

0.754

High

1065679

CTIP
DNA endonuclease RBBP8

6

3

Small-scale

0.734

High

629107

CCNA2
Cyclin-A2

6

7

Small-scale

0.732

High

1065668

LIN9
Protein lin-9 homolog

6

5

Small-scale

0.732

High

718886

CCND3
G1/S-specific cyclin-D3

5

20

Small-scale

0.723

High

1065677

LIN37
Protein lin-37 homolog

5

3

Small-scale

0.714

High

1065645

RBBP4
Histone-binding protein RBBP4

3

9

Small-scale

0.667

High

1065670

LIN54
Protein lin-54 homolog

3

5

Small-scale

0.667

High

718806

CCND2
G1/S-specific cyclin-D2

3

18

High-throughput

0.667

High

1065664

E2F5
Transcription factor E2F5

3

20

Small-scale

0.660

High

1065650

HDAC1
Histone deacetylase 1

3

12

Small-scale

0.650

High

1065656

TFDP2
Transcription factor Dp-2

2

11

Small-scale

0.635

High

549131

CDK4
Cyclin-dependent kinase 4

2

19

Small-scale

0.634

High

1029066

E2F1
Transcription factor E2F1

3

20

Small-scale

0.633

High

766489

PHB1
Prohibitin 1

2

2

Small-scale

0.631

High

1065667

LIN52
Protein lin-52 homolog

2

3

Small-scale

0.629

High

565517

RARG
Retinoic acid receptor gamma

2

3

High-throughput

0.628

High

1065687

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

14

High-throughput

0.628

High

994189

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

5

Small-scale

0.619

High

808035

CDN1A
Cyclin-dependent kinase inhibitor 1

2

3

High-throughput

0.611

High

1065672

TXD11
Thioredoxin domain-containing protein 11

3

2

High-throughput

0.609

High

799035

BRCA1
Breast cancer type 1 susceptibility protein

2

3

Small-scale

0.595

High

1065648

SKP2
S-phase kinase-associated protein 2

2

2

Small-scale

0.595

High

666979

CCNE1
G1/S-specific cyclin-E1

2

12

Small-scale

0.584

High

1036507

ID2
DNA-binding protein inhibitor ID-2

2

3

Small-scale

0.584

High

400717

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

Small-scale

0.573

High

1065671

RINT1
RAD50-interacting protein 1

1

2

Small-scale

0.573

High

1065646

TP53B
TP53-binding protein 1

1

1

Small-scale

0.561

High

1065665

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

Small-scale

0.561

High

1065676

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

Small-scale

0.561

High

1065678

NEB2
Neurabin-2

1

2

Small-scale

0.561

High

1065655

TFDP1
Transcription factor Dp-1

1

11

Small-scale

0.554

High

1025331

CDK6
Cyclin-dependent kinase 6

1

20

Small-scale

0.550

High

573809

CCNB1
G2/mitotic-specific cyclin-B1

1

7

High-throughput

0.536

High

625335

CSK22
Casein kinase II subunit alpha'

1

16

High-throughput

0.536

High

714064

PML
Protein PML

1

3

Small-scale

0.536

High

964593

DCAF7
DDB1- and CUL4-associated factor 7

1

12

High-throughput

0.536

High

997672

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

1017408

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.536

High

1023532

CYC
Cytochrome c

1

1

High-throughput

0.536

High

1065654

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.536

High

1065661

IRF3
Interferon regulatory factor 3

1

2

High-throughput

0.536

High

1065680

CITE1
Cbp/p300-interacting transactivator 1

1

2

High-throughput

0.536

High

1065652

DGKZ
Diacylglycerol kinase zeta

1

5

Small-scale

0.534

High

608970

XBP1
X-box-binding protein 1

1

0

High-throughput

0.518

High

961597

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.518

High

116817

I6L8A6
DNA endonuclease RBBP8

1

3

High-throughput

0.515

High

756165

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.501

High

1007627

CCNA1
Cyclin-A1

1

7

Small-scale

0.501

High

1065647

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.501

High

1065651

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.501

High

355346

CCNE2
G1/S-specific cyclin-E2

1

14

Small-scale

0.484

High

248289

HBP1
HMG box-containing protein 1

1

3

Small-scale

0.481

High

664720

CCND1
G1/S-specific cyclin-D1

1

20

Small-scale

0.481

High

903335

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.481

High

916121

LBX1
Transcription factor LBX1

1

2

Small-scale

0.481

High

216422

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

296399

RBBP9
Serine hydrolase RBBP9

1

4

Small-scale

0.479

High

581650

MYOD1
Myoblast determination protein 1

1

5

Small-scale

0.479

High

639721

TAF1
Transcription initiation factor TFIID subunit 1

1

6

Small-scale

0.479

High

897766

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.479

High

1065649

CTBP1
C-terminal-binding protein 1

1

2

Small-scale

0.479

High

1065653

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1065660

BECN1
Beclin-1

1

2

Small-scale

0.479

High

1065662

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.479

High

1065683

AATF
Protein AATF

1

2

Small-scale

0.479

High

1065684

YETS2
YEATS domain-containing protein 2

1

1

High-throughput

0.479

High

1065685

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

1065686

PA2G4
Proliferation-associated protein 2G4

1

2

Small-scale

0.479

High

460915

LDHC
L-lactate dehydrogenase C chain

1

0

Small-scale

0.460

High

1065658

DCTN1
Dynactin subunit 1

1

0

Small-scale

0.460

High

992151

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1065659

FA50A
Protein FAM50A

1

0

High-throughput

0.458

High

1065675

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

413711

P53
Cellular tumor antigen p53

1

3

High-throughput

0.445

High

1065673

FBX11
F-box only protein 11

1

1

High-throughput

0.445

High

424502

PAI2
Plasminogen activator inhibitor 2

1

1

Small-scale

0.437

High

1065663

CDK10
Cyclin-dependent kinase 10

1

11

High-throughput

0.437

High

1065674

SNX19
Sorting nexin-19

1

2

Small-scale

0.437

High

636843

GSTM3
Glutathione S-transferase Mu 3

1

0

Small-scale

0.426

High

1065681

ISCU
Iron-sulfur cluster assembly enzyme ISCU

1

0

Small-scale

0.426

High

541971

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

1065657

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

1065669

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.251

Low

1065682

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025