HitPredict

Interactor 1: NPL4 (P33755)
Nuclear protein localization protein 4 (HMG-CoA reductase degradation protein 4)
Gene: NPL4

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 0.60 0.664

The method score is based on:

Property Details
Experiments 25215493, 16619026, 16179953
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0030970 - retrograde protein transport, ER to cytosol
GO:0036503 - ERAD pathway
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 580
Sc

1 551
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024