Protein: PSA3
Proteasome subunit alpha type-3 (Macropain subunit Y13) (Multicatalytic endopeptidase complex subunit Y13) (Proteasome component Y13) (Proteinase YSCE subunit 13)

Gene: PSA3, PRE9
Organism: Saccharomyces cerevisiae S288C
Interactions: 101
UniProt ID: P23638

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645124

PSB4
Proteasome subunit beta type-4

15

20

Small-scale

0.982

High

661370

PSA2
Proteasome subunit alpha type-2

10

19

Small-scale

0.977

High

636539

PSA7
Probable proteasome subunit alpha type-7

7

19

Small-scale

0.963

High

661382

PSB5
Proteasome subunit beta type-5

7

20

Small-scale

0.958

High

636625

PSA1
Proteasome subunit alpha type-1

5

20

Small-scale

0.922

High

661413

PSA4
Proteasome subunit alpha type-4

5

19

Small-scale

0.922

High

661412

PSA6
Proteasome subunit alpha type-6

4

19

Small-scale

0.884

High

661372

PSB2
Proteasome subunit beta type-2

4

20

Small-scale

0.881

High

661375

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.839

High

661402

UMP1
Proteasome maturation factor UMP1

4

0

Small-scale

0.836

High

661431

PRS8
26S proteasome regulatory subunit 8 homolog

3

20

Small-scale

0.827

High

661371

PSB6
Proteasome subunit beta type-6

2

20

High-throughput

0.776

High

661383

PSB7
Proteasome subunit beta type-7

2

20

High-throughput

0.776

High

661385

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.776

High

661403

PSB1
Proteasome subunit beta type-1

2

20

High-throughput

0.776

High

661419

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

12

20

Small-scale

0.755

High

661392

PRS6A
26S proteasome regulatory subunit 6A

2

20

High-throughput

0.754

High

661394

PRS7
26S proteasome regulatory subunit 7 homolog

2

20

High-throughput

0.754

High

661414

PRS4
26S proteasome regulatory subunit 4 homolog

2

20

High-throughput

0.754

High

661447

RPN5
26S proteasome regulatory subunit RPN5

2

20

Small-scale

0.754

High

661449

RPN6
26S proteasome regulatory subunit RPN6

2

20

High-throughput

0.754

High

661418

BLM10
Proteasome activator BLM10

2

8

Small-scale

0.727

High

661442

RPN8
26S proteasome regulatory subunit RPN8

4

20

Small-scale

0.691

High

661406

RPN10
26S proteasome regulatory subunit RPN10

3

12

High-throughput

0.662

High

509409

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

20

Small-scale

0.633

High

661378

FUB1
Silencing boundary-establishment protein FUB1

2

0

Small-scale

0.631

High

661446

POC4
Proteasome chaperone 4

1

0

Small-scale

0.631

High

661369

PSA3
Proteasome subunit alpha type-3

1

19

High-throughput

0.618

High

661393

PRS6B
26S proteasome regulatory subunit 6B homolog

1

20

High-throughput

0.618

High

661424

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

661386

RPN12
26S proteasome regulatory subunit RPN12

2

4

Small-scale

0.586

High

661396

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.586

High

661441

POC3
Proteasome chaperone 3

1

0

Small-scale

0.586

High

661404

ECM29
Proteasome component ECM29

2

13

High-throughput

0.584

High

661405

RPN1
26S proteasome regulatory subunit RPN1

2

20

Small-scale

0.584

High

661439

RPN7
26S proteasome regulatory subunit RPN7

2

20

High-throughput

0.584

High

661377

PWP2
Periodic tryptophan protein 2

2

3

High-throughput

0.567

High

661391

SUI1
Eukaryotic translation initiation factor eIF-1

2

4

Small-scale

0.555

High

661411

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

661379

KCC1
Calcium/calmodulin-dependent protein kinase I

2

3

High-throughput

0.550

High

661437

POC1
Proteasome chaperone 1

1

0

High-throughput

0.517

High

661380

CIN8
Kinesin-like protein CIN8

1

5

High-throughput

0.515

High

661423

YG2A
Zinc finger protein YGR067C

1

19

High-throughput

0.515

High

441040

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

602324

PHO85
Cyclin-dependent protein kinase PHO85

1

7

High-throughput

0.501

High

661395

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.501

High

661434

TDA1
Serine/threonine-protein kinase TDA1

1

6

High-throughput

0.501

High

660827

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

0

High-throughput

0.493

High

661389

PMD1
Negative regulator of sporulation PMD1

1

0

High-throughput

0.493

High

661399

CND2
Condensin complex subunit 2

1

0

High-throughput

0.493

High

661417

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

High-throughput

0.493

High

661445

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.493

High

419362

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

419610

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

578885

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

661373

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

661374

BPH1
Beige protein homolog 1

1

5

High-throughput

0.479

High

661381

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

661387

RPN2
26S proteasome regulatory subunit RPN2

1

20

High-throughput

0.479

High

661388

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

661390

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

661401

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

661410

RPN3
26S proteasome regulatory subunit RPN3

1

8

High-throughput

0.479

High

661420

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

12

High-throughput

0.479

High

661426

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

661427

H3
Histone H3

1

1

High-throughput

0.479

High

661429

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

Small-scale

0.479

High

661433

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

661435

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

661436

RPN9
26S proteasome regulatory subunit RPN9

1

12

High-throughput

0.479

High

661443

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

661450

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

661432

MLP1
Protein MLP1

1

3

High-throughput

0.470

High

661428

ACAC
Acetyl-CoA carboxylase

1

0

Small-scale

0.460

High

150261

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

314842

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.458

High

434845

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

441719

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

502863

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

504048

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

661384

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

661407

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

661430

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

661398

AKL1
Serine/threonine-protein kinase AKL1

1

4

High-throughput

0.457

High

661421

TOS3
Serine/threonine-protein kinase TOS3

1

4

High-throughput

0.457

High

523113

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

649470

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.445

High

661376

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

661425

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.445

High

661409

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.437

High

661415

MLP2
Protein MLP2

1

4

High-throughput

0.437

High

661440

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

661444

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

661448

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

661397

YK50
Mitochondrial hydrolase YKR070W

1

0

High-throughput

0.269

Low

661416

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.269

Low

661422

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

0

High-throughput

0.269

Low

661400

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

661438

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

661408

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025