HitPredict

Interactor 1: H2B1B (P33778)
Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)
Gene: H2BC3

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36598580
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 4911
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		SUV91_HUMAN (4579-4910): 8.61e-90: 302: 19.18
+	Hs
		1079994 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		1080205 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		331825 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		1087385 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		707738 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		165638 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		1059648 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1059777 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		707635 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		975269 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		1018625 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		241509 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		707596 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		707612 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		1087342 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		NSD1_HUMAN (1010-1602): 1.56e-13: 80.4: 11.26
+	Hs
		1274410 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		NSD1_HUMAN (1010-1602): 1.56e-13: 80.4: 11.26
+	Hs
		1087307 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		1087483 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82