Protein: MTHR1
Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)

Gene: MTHR1, MET12
Organism: Saccharomyces cerevisiae S288C
Interactions: 27
UniProt ID: P46151

Gene Ontology (top 5):
GO:0004489 - methylenetetrahydrofolate reductase [NAD(P)H] activity
GO:0009086 - methionine biosynthetic process
GO:0035999 - tetrahydrofolate interconversion
GO:0071949 - FAD binding
GO:0106312 - methylenetetrahydrofolate reductase (NADH) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856206

MTHR2
Methylenetetrahydrofolate reductase 2

3

2

Small-scale

0.848

High

524344

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.489

High

856207

METX
Putative cystathionine gamma-synthase YML082W

1

1

High-throughput

0.479

High

509611

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.457

High

748863

SWE1
Mitosis inhibitor protein kinase SWE1

1

1

High-throughput

0.457

High

707453

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

392938

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.407

High

527008

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.407

High

545332

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

579620

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

727131

HS104
Heat shock protein 104

1

1

High-throughput

0.407

High

739400

ZUO1
Zuotin

1

3

High-throughput

0.407

High

741834

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.407

High

752420

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

819091

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

676842

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.269

Low

441177

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.261

Low

602532

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.261

Low

750267

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

815483

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.261

Low

822255

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

795063

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

590204

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.238

Low

510601

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

597188

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.232

Low

804250

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.232

Low

823270

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025