HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 857 Hs			1 618
+	Hs
		708281 TTK_HUMAN (1-857): 0: 776: 100.00		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		545401 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		925307 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		894056 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		951021 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Hs
		925308 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Ce
		104463 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		G5EBV3_CAEEL (3-186): 3.6e-74: 237: 23.23
+	Ce
		107919 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		RAC1_CAEEL (3-177): 2.15e-73: 235: 25.40
+	Hs
		915705 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900513 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		915706 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900514 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		1082036 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		436326 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		120458 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		915766 PKN3_HUMAN (49-854): 3.01e-144: 450: 14.95		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900594 PKN3_HUMAN (49-854): 3.01e-144: 450: 14.95		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Ce
		107920 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		RHO1_CAEEL (6-168): 8.76e-11: 63.5: 28.81
+	Hs
		296515 KPCD3_HUMAN (174-853): 3.32e-129: 411: 15.32		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		915949 KPCD2_HUMAN (140-855): 7.56e-120: 386: 14.74		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38