HitPredict

Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Interactor 2: MCM10 (Q7L590)
Protein MCM10 homolog (HsMCM10)
Gene: MCM10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 875
+	Hs
		832547 MCM2_HUMAN (2-839): 0: 762: 27.95		MCM10_HUMAN (1-875): 0: 1197: 100.00
+	Hs
		1055585 MCM6_HUMAN (138-842): 0: 675: 26.97		MCM10_HUMAN (1-875): 0: 1197: 100.00
+	Hs
		708959 MCM7_HUMAN (158-841): 0: 660: 29.88		MCM10_HUMAN (1-875): 0: 1197: 100.00
+	Hs
		1055575 MCM6_HUMAN (138-842): 0: 675: 26.97		Q5T670_HUMAN (1-848): 0: 1151: 99.76
+	Dm
		832229 MCM2_DROME (40-812): 0: 724: 27.85		MCM10_DROME (61-866): 0: 621: 27.30
+	Sc
		675509 MCM4_YEAST (1-862): 0: 745: 41.83		MCM10_YEAST (107-598): 3.03e-153: 463: 19.07
+	Sc
		667551 MCM2_YEAST (4-784): 0: 688: 26.05		MCM10_YEAST (107-598): 3.03e-153: 463: 19.07
+	Sc
		667837 MCM5_YEAST (156-840): 0: 688: 30.08		MCM10_YEAST (107-598): 3.03e-153: 463: 19.07
+	Sp
		193962 MCM4_SCHPO (6-855): 0: 749: 42.14		MCM10_SCHPO (111-491): 2.64e-116: 368: 21.70
+	Sp
		193966 MCM2_SCHPO (28-772): 0: 710: 27.96		MCM10_SCHPO (111-491): 2.64e-116: 368: 21.70
+	Sp
		193967 MCM5_SCHPO (156-861): 0: 681: 31.65		MCM10_SCHPO (111-491): 2.64e-116: 368: 21.70
+	Sp
		193968 MCM6_SCHPO (95-863): 0: 653: 28.89		MCM10_SCHPO (111-491): 2.64e-116: 368: 21.70