HitPredict

Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Interactor 2: ASF1A (Q9Y294)
Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)
Gene: ASF1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 22407294
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 204
+	Hs
		708527 MCM4_HUMAN (1-863): 0: 952: 100.00		ASF1B_HUMAN (1-204): 9.25e-121: 342: 70.59
+	Hs
		832791 MCM2_HUMAN (2-839): 0: 762: 27.95		ASF1A_HUMAN (1-204): 2.31e-128: 361: 100.00
+	Hs
		832738 MCM2_HUMAN (2-839): 0: 762: 27.95		ASF1B_HUMAN (1-204): 9.25e-121: 342: 70.59
+	Hs
		708784 MCM5_HUMAN (133-846): 0: 698: 30.23		ASF1B_HUMAN (1-204): 9.25e-121: 342: 70.59
+	Hs
		1055662 MCM6_HUMAN (138-842): 0: 675: 26.97		ASF1A_HUMAN (1-204): 2.31e-128: 361: 100.00
+	Hs
		709117 MCM7_HUMAN (158-841): 0: 660: 29.88		ASF1A_HUMAN (1-204): 2.31e-128: 361: 100.00
+	Hs
		1055640 MCM6_HUMAN (138-842): 0: 675: 26.97		ASF1B_HUMAN (1-204): 9.25e-121: 342: 70.59
+	Dm
		832226 MCM2_DROME (40-812): 0: 724: 27.85		ASF1_DROME (1-203): 1.05e-97: 284: 56.88
+	Hs
		709077 MCM7_HUMAN (158-841): 0: 660: 29.88		ASF1B_HUMAN (1-204): 9.25e-121: 342: 70.59
+	Sc
		667552 MCM2_YEAST (4-784): 0: 688: 26.05		ASF1_YEAST (1-168): 7.8e-88: 261: 54.76