HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: CDC6 (Q99741)
Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)
Gene: CDC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	23405012, 12614612, 10464337
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006270 - DNA replication initiation and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 719 Hs			1 560
+	Hs
		708744 MCM5_HUMAN (6-716): 0: 682: 27.61		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		832668 MCM2_HUMAN (8-690): 0: 643: 28.13		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		708888 MCM7_HUMAN (1-719): 0: 786: 100.00		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		217780 MCM7_HUMAN (1-719): 0: 786: 100.00		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Hs
		708627 MCM5_HUMAN (6-716): 0: 682: 27.61		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		832428 MCM2_HUMAN (8-690): 0: 643: 28.13		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		708434 MCM4_HUMAN (5-700): 0: 636: 31.52		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		1033381 MCM6_HUMAN (3-715): 0: 623: 28.05		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Sc
		667877 MCM5_YEAST (5-716): 0: 666: 27.77		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		675544 MCM4_YEAST (7-703): 0: 658: 29.69		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		744785 MCM7_YEAST (2-719): 0: 643: 45.41		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		447786 MCM5_YEAST (5-716): 0: 666: 27.77		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54
+	Hs
		217789 MCM2_HUMAN (8-690): 0: 643: 28.13		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Hs
		217779 MCM4_HUMAN (5-700): 0: 636: 31.52		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Sc
		858999 MCM6_YEAST (9-704): 0: 616: 29.69		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		447792 MCM7_YEAST (2-719): 0: 643: 45.41		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54
+	Hs
		217802 MCM6_HUMAN (3-715): 0: 623: 28.05		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49