Protein: T2EB
Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)

Gene: T2EB, GTF2E2
Organism: Homo sapiens
Interactions: 154
UniProt ID: P29084

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005669 - transcription factor TFIID complex
GO:0005673 - transcription factor TFIIE complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708874

T2EA
General transcription factor IIE subunit 1

12

6

Small-scale

0.982

High

569062

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.647

High

708948

VIGLN
Vigilin

3

0

High-throughput

0.638

High

217063

MS18B
Protein Mis18-beta

3

0

High-throughput

0.634

High

709023

MS18A
Protein Mis18-alpha

3

0

High-throughput

0.634

High

708929

FEN1
Flap endonuclease 1

2

1

High-throughput

0.628

High

709020

RBM12
RNA-binding protein 12

2

1

High-throughput

0.628

High

709026

DBNL
Drebrin-like protein

2

1

High-throughput

0.628

High

708923

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.614

High

708928

T2FA
General transcription factor IIF subunit 1

2

1

Small-scale

0.602

High

227062

SYNC
Asparagine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

291906

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

0

High-throughput

0.602

High

295290

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

High-throughput

0.602

High

479199

THIK
3-ketoacyl-CoA thiolase, peroxisomal

2

0

High-throughput

0.602

High

708924

TPP2
Tripeptidyl-peptidase 2

2

0

High-throughput

0.602

High

708926

BLVRB
Flavin reductase

2

0

High-throughput

0.602

High

708930

EFTS
Elongation factor Ts, mitochondrial

2

0

High-throughput

0.602

High

708934

GUAA
GMP synthase [glutamine-hydrolyzing]

2

0

High-throughput

0.602

High

708940

SYYC
Tyrosine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

708942

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.602

High

708947

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

2

0

High-throughput

0.602

High

708954

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

0

High-throughput

0.602

High

708958

PP1R8
Nuclear inhibitor of protein phosphatase 1

2

0

High-throughput

0.602

High

708959

CSTF3
Cleavage stimulation factor subunit 3

2

0

High-throughput

0.602

High

708964

MDC1
Mediator of DNA damage checkpoint protein 1

2

0

High-throughput

0.602

High

708965

PSF1
DNA replication complex GINS protein PSF1

2

0

High-throughput

0.602

High

708970

PMVK
Phosphomevalonate kinase

2

0

High-throughput

0.602

High

708973

TOM34
Mitochondrial import receptor subunit TOM34

2

0

High-throughput

0.602

High

708978

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

2

0

High-throughput

0.602

High

708979

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

0

High-throughput

0.602

High

708991

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

0

High-throughput

0.602

High

709001

DNJC2
DnaJ homolog subfamily C member 2

2

0

High-throughput

0.602

High

709002

VRK1
Serine/threonine-protein kinase VRK1

2

0

High-throughput

0.602

High

709003

PYM1
Partner of Y14 and mago

2

0

High-throughput

0.602

High

709006

PDC10
Programmed cell death protein 10

2

0

High-throughput

0.602

High

709008

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

2

0

High-throughput

0.602

High

709011

SLK
STE20-like serine/threonine-protein kinase

2

0

High-throughput

0.602

High

709014

UBE2T
Ubiquitin-conjugating enzyme E2 T

2

0

High-throughput

0.602

High

709018

PHP14
14 kDa phosphohistidine phosphatase

2

0

High-throughput

0.602

High

709019

SYFB
Phenylalanine--tRNA ligase beta subunit

2

0

High-throughput

0.602

High

709031

SBDS
Ribosome maturation protein SBDS

2

0

High-throughput

0.602

High

709033

TLN1
Talin-1

2

0

High-throughput

0.602

High

709034

PPME1
Protein phosphatase methylesterase 1

2

0

High-throughput

0.602

High

709035

SNX5
Sorting nexin-5

2

0

High-throughput

0.602

High

708937

CDK7
Cyclin-dependent kinase 7

2

1

Small-scale

0.595

High

708949

TF2B
Transcription initiation factor IIB

2

1

Small-scale

0.595

High

708988

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.580

High

708994

KAT5
Histone acetyltransferase KAT5

2

0

High-throughput

0.580

High

709017

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

421552

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

628709

TBP
TATA-box-binding protein

2

0

Small-scale

0.577

High

708939

TF2AA
Transcription initiation factor IIA subunit 1

2

0

Small-scale

0.577

High

690459

KAD4
Adenylate kinase 4, mitochondrial

2

1

High-throughput

0.574

High

708953

EF1A2
Elongation factor 1-alpha 2

2

1

High-throughput

0.574

High

708975

ACTBL
Beta-actin-like protein 2

2

1

High-throughput

0.574

High

709010

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.574

High

659363

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.558

High

395545

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

365743

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.536

High

581438

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

708952

CSTF1
Cleavage stimulation factor subunit 1

1

1

High-throughput

0.536

High

709036

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

High-throughput

0.536

High

48338

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.513

High

258074

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.513

High

288844

LYPA1
Acyl-protein thioesterase 1

1

0

High-throughput

0.513

High

291622

XRP2
Protein XRP2

1

0

High-throughput

0.513

High

329701

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.513

High

541846

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

603176

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

708927

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.513

High

708938

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.513

High

708961

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.513

High

708971

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

708974

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.513

High

708989

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

708995

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

708999

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.513

High

709004

SLD5
DNA replication complex GINS protein SLD5

1

0

High-throughput

0.513

High

709005

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.513

High

709009

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

709016

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.513

High

709028

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.513

High

709029

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

709030

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.513

High

370576

FOS
Protein c-Fos

1

1

Small-scale

0.501

High

622763

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

1

Small-scale

0.501

High

595954

H12
Histone H1.2

1

0

High-throughput

0.493

High

708956

GRSF1
G-rich sequence factor 1

1

1

Small-scale

0.481

High

429360

JUN
Transcription factor Jun

1

0

Small-scale

0.480

High

654092

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.480

High

708950

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.480

High

708962

KLF5
Krueppel-like factor 5

1

0

Small-scale

0.480

High

708983

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.480

High

259492

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

468098

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

667181

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

708925

PML
Protein PML

1

1

High-throughput

0.479

High

708932

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

708944

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

708957

NFIA
Nuclear factor 1 A-type

1

1

High-throughput

0.479

High

708968

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.479

High

708981

MCAF1
Activating transcription factor 7-interacting protein 1

1

2

Small-scale

0.479

High

131335

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.458

High

316759

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

325695

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

400332

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

484942

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

552758

TPR
Nucleoprotein TPR

1

0

High-throughput

0.458

High

557884

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

708931

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

708936

DYN2
Dynamin-2

1

0

High-throughput

0.458

High

708941

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.458

High

708943

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

708945

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

708946

H31
Histone H3.1

1

0

High-throughput

0.458

High

708960

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

708969

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

708985

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

708987

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

708993

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.458

High

708996

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

708997

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.458

High

709000

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

709007

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

709015

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

709022

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

709024

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

709032

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

708986

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

708963

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

708967

CASP8
Caspase-8

1

0

High-throughput

0.426

High

708976

HS904
Putative heat shock protein HSP 90-alpha A4

1

2

High-throughput

0.407

High

189427

STX7
Syntaxin-7

2

0

High-throughput

0.328

High

708966

MESD
LRP chaperone MESD

2

0

High-throughput

0.328

High

708980

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

2

0

High-throughput

0.328

High

708984

HDGR2
Hepatoma-derived growth factor-related protein 2

2

0

High-throughput

0.328

High

708998

EFHD2
EF-hand domain-containing protein D2

2

0

High-throughput

0.328

High

709012

LRC40
Leucine-rich repeat-containing protein 40

2

0

High-throughput

0.328

High

709021

CYRIB
CYFIP-related Rac1 interactor B

2

0

High-throughput

0.328

High

709025

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

0

High-throughput

0.328

High

709027

MCTS1
Malignant T-cell-amplified sequence 1

2

0

High-throughput

0.328

High

516939

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

2

0

High-throughput

0.288

High

295804

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.279

Low

708935

GBG10

1

0

High-throughput

0.279

Low

708955

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.279

Low

708972

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

0

High-throughput

0.279

Low

708977

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

708992

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.279

Low

709013

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

708933

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.249

Low

708982

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

708990

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.249

Low

708951

TAGL
Transgelin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025