HitPredict

Interactor 1: VPS35 (P34110)
Vacuolar protein sorting-associated protein 35 (Vacuolar protein-targeting protein 7)
Gene: VPS35

Interactor 2: MVP1 (P40959)
Sorting nexin MVP1
Gene: MVP1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.613

Property	Details
Experiments	18467557, 22615397
Identification Methods	protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0042147 - retrograde transport, endosome to Golgi
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 944 Sc			1 511
+	Sc
		710083 VPS35_YEAST (1-944): 0: 1259: 100.00		VPS5_YEAST (46-499): 2.08e-58: 206: 15.95
+	Sc
		710076 VPS35_YEAST (1-944): 0: 1259: 100.00		SNX3_YEAST (139-238): 7.09e-11: 62.5: 30.48
+	Mm
		1322295 VPS35_MOUSE (7-856): 0: 870: 31.37		SNX1_MOUSE (4-506): 1.34e-82: 267: 14.15
+	Hs
		1040506 VPS35_HUMAN (7-856): 0: 869: 31.49		SNX1_HUMAN (4-506): 4.13e-80: 261: 13.59
+	Ce
		1094069 Q21053_CAEEL (7-842): 0: 836: 29.07		Q9GYJ9_CAEEL (54-508): 1.57e-66: 224: 14.85
+	Hs
		234983 VPS35_HUMAN (7-856): 0: 869: 31.49		SNX3_HUMAN (106-250): 2.53e-36: 133: 29.94
+	Dm
		1365832 Q9W277_DROME (7-857): 0: 927: 31.69		Q9VG51_DROME (146-240): 6.57e-14: 71.3: 34.95
+	Tt
		101891 G0S709_CHATD (7-853): 0: 784: 35.85		G0SH11_CHATD (128-503): 2.98e-53: 191: 14.70
+	Hs
		1300514 VPS35_HUMAN (7-856): 0: 869: 31.49		SNX12_HUMAN (146-244): 2.23e-12: 67.1: 31.78