HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: NR3L1 (Q68D85)
Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)
Gene: NCR3LG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	28514442, 33961781, 35384245, 21875946
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 454
+	Hs
		713822 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CD276_HUMAN (1-396): 1.95e-39: 150: 18.01
+	Hs
		545076 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PVR_HUMAN (18-261): 5.52e-32: 128: 23.29
+	Hs
		713858 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		NECT2_HUMAN (21-261): 2.04e-31: 128: 20.23
+	Hs
		713800 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CD166_HUMAN (8-259): 1.78e-30: 125: 15.89
+	Hs
		382280 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		382324 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		508012 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		NECT1_HUMAN (12-244): 1.16e-24: 108: 19.01
+	Hs
		545114 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		PVR_HUMAN (18-261): 5.52e-32: 128: 23.29
+	Hs
		609294 FGFR3_HUMAN (137-601): 1.51e-144: 440: 27.04		NECT1_HUMAN (12-244): 1.16e-24: 108: 19.01
+	Hs
		382433 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		382306 FGFR2_HUMAN (139-601): 5.39e-134: 413: 26.40		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		384783 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		BT1A1_HUMAN (24-350): 3.74e-31: 127: 13.07
+	Hs
		384808 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		CD166_HUMAN (8-259): 1.78e-30: 125: 15.89
+	Hs
		382259 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		601514 FGFR2_HUMAN (139-601): 5.39e-134: 413: 26.40		NECT1_HUMAN (12-244): 1.16e-24: 108: 19.01
+	Hs
		507819 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		NCAM1_HUMAN (13-299): 1.16e-14: 78.6: 12.03
+	Hs
		530154 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		NCAM1_HUMAN (13-299): 1.16e-14: 78.6: 12.03
+	Hs
		508005 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		OPCM_HUMAN (150-368): 5.44e-11: 65.9: 10.96
+	Mm
		530201 NTRK2_MOUSE (15-607): 2.45e-130: 403: 22.33		NCAM1_MOUSE (13-309): 2.43e-14: 77.8: 12.29
+	Hs
		384188 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		NCAM1_HUMAN (13-299): 1.16e-14: 78.6: 12.03