HitPredict

Interactor 1: HS71L (P34931)
Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L)
Gene: HSPA1L

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 641 Hs			1 840
+	Hs
		564020 HSP76_HUMAN (1-641): 0: 957: 79.47		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		503544 HSP7C_HUMAN (4-615): 0: 946: 84.80		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		483777 HS71B_HUMAN (1-641): 0: 938: 88.80		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		714156 HSP72_HUMAN (3-641): 0: 934: 81.90		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		1120566 Q53FA3_HUMAN (1-641): 0: 977: 99.69		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		714034 HS71L_HUMAN (1-641): 0: 977: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		320802 HSP7C_HUMAN (4-615): 0: 946: 84.80		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		320833 HSP72_HUMAN (3-641): 0: 934: 81.90		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		504490 HSP7C_HUMAN (4-615): 0: 946: 84.80		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		503543 HS71L_HUMAN (1-641): 0: 977: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503389 HSP76_HUMAN (1-641): 0: 957: 79.47		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503315 HSP7C_HUMAN (4-615): 0: 946: 84.80		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		926115 HSP7C_MOUSE (4-615): 0: 945: 84.97		HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15
+	Mm
		571859 HS71B_MOUSE (4-641): 0: 945: 86.90		HS71A_MOUSE (571-686): 1e-17: 89.7: 23.08
+	Hs
		503752 HSP72_HUMAN (3-641): 0: 934: 81.90		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564046 HSP72_HUMAN (3-641): 0: 934: 81.90		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		871593 HSP72_HUMAN (3-641): 0: 934: 81.90		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86