HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: DNJC3 (Q13217)
DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
Gene: DNAJC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11116152
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 504
+	Hs
		714375 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJC7_HUMAN (31-503): 8.06e-69: 230: 26.05
+	Hs
		320902 HS74L_HUMAN (1-840): 0: 959: 63.21		DNJC7_HUMAN (31-503): 8.06e-69: 230: 26.05
+	Hs
		1267736 HS105_HUMAN (1-840): 0: 938: 62.95		DNJC7_HUMAN (31-503): 8.06e-69: 230: 26.05
+	Hs
		714317 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB8_HUMAN (394-501): 4.62e-39: 143: 38.79
+	Hs
		279281 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB5_HUMAN (392-495): 4.16e-36: 139: 39.13
+	Hs
		636462 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB2_HUMAN (394-501): 1.3e-34: 134: 41.88
+	Hs
		714326 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB3_HUMAN (394-499): 9.96e-36: 131: 38.60
+	Hs
		320815 HS74L_HUMAN (1-840): 0: 959: 63.21		DNJB2_HUMAN (394-501): 1.3e-34: 134: 41.88
+	Hs
		279330 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB5_HUMAN (392-495): 4.16e-36: 139: 39.13
+	Hs
		684440 HSP74_HUMAN (1-840): 0: 993: 100.00		STIP1_HUMAN (24-460): 7.31e-16: 82: 10.91
+	Hs
		714418 HSP74_HUMAN (1-840): 0: 993: 100.00		RPAP3_HUMAN (133-409): 4.41e-10: 64.2: 12.20
+	Hs
		320819 HS74L_HUMAN (1-840): 0: 959: 63.21		STIP1_HUMAN (24-460): 7.31e-16: 82: 10.91
+	Hs
		684925 HS105_HUMAN (1-840): 0: 938: 62.95		STIP1_HUMAN (24-460): 7.31e-16: 82: 10.91
+	Hs
		258129 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB6_HUMAN (394-459): 4.92e-14: 75.1: 56.06
+	Ce
		450534 HSP1_CAEEL (2-603): 0: 811: 31.48		Q20774_CAEEL (392-499): 2.85e-37: 141: 38.33
+	Dm
		1371973 Q9VUC1_DROME (1-840): 0: 821: 42.10		Q9VPN5_DROME (18-164): 4.46e-22: 100: 17.69
+	Dm
		1096122 Q9VUC1_DROME (1-840): 0: 821: 42.10		DNAJ1_DROME (393-465): 1.26e-12: 70.9: 52.70
+	Sc
		542113 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		CYC8_YEAST (33-390): 1.82e-33: 137: 10.71
+	Sc
		694716 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		XDJ1_YEAST (396-478): 1.05e-12: 72: 46.99
+	Hs
		174578 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		OGT1_HUMAN (13-134): 3.34e-16: 84: 18.03