Protein: PHF3
PHD finger protein 3

Gene: PHF3
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q92576

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0006351 - DNA-templated transcription
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

980972

H2B1C
Histone H2B type 1-C/E/F/G/I

2

12

High-throughput

0.754

High

998618

H31
Histone H3.1

2

15

High-throughput

0.754

High

478137

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.691

High

775233

FUS
RNA-binding protein FUS

1

1

High-throughput

0.691

High

1104322

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.691

High

1160227

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.691

High

1163102

H2B2E
Histone H2B type 2-E

1

12

High-throughput

0.691

High

1365094

H2AJ
Histone H2A.J

1

6

High-throughput

0.691

High

130561

SPT5H
Transcription elongation factor SPT5

3

5

High-throughput

0.667

High

1161967

H31T
Histone H3.1t

1

15

High-throughput

0.665

High

966691

1433G
14-3-3 protein gamma

3

5

High-throughput

0.650

High

691808

MK03
Mitogen-activated protein kinase 3

2

7

High-throughput

0.628

High

1036537

ID2
DNA-binding protein inhibitor ID-2

2

1

High-throughput

0.628

High

256940

H2B1K
Histone H2B type 1-K

1

12

High-throughput

0.618

High

260233

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.618

High

1017070

H33
Histone H3.3

1

15

High-throughput

0.618

High

1097456

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.618

High

990560

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.611

High

1049630

1433F
14-3-3 protein eta

3

5

High-throughput

0.609

High

1365091

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.602

High

703670

MK01
Mitogen-activated protein kinase 1

2

7

High-throughput

0.601

High

730109

1433B
14-3-3 protein beta/alpha

2

5

High-throughput

0.601

High

1365096

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.595

High

485299

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.586

High

372716

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

396621

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

158663

TYB4Y
Thymosin beta-4, Y-chromosomal

1

1

High-throughput

0.536

High

164035

NDC80
Kinetochore protein NDC80 homolog

1

2

High-throughput

0.536

High

480248

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

542140

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

574397

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

879739

MAPK2
MAP kinase-activated protein kinase 2

1

3

High-throughput

0.536

High

973999

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.536

High

1023585

CYC
Cytochrome c

1

2

High-throughput

0.536

High

1065332

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

1365107

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.536

High

660694

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.517

High

595539

H15
Histone H1.5

1

3

High-throughput

0.515

High

596272

H12
Histone H1.2

1

2

High-throughput

0.515

High

765752

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.515

High

772934

MYH9
Myosin-9

1

1

High-throughput

0.515

High

987432

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.515

High

1294346

ZN677
Zinc finger protein 677

1

0

High-throughput

0.513

High

889476

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.501

High

964392

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

601789

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.493

High

169201

QCR10
Cytochrome b-c1 complex subunit 10

1

1

High-throughput

0.489

High

317079

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

1

High-throughput

0.489

High

515894

SAA1
Serum amyloid A-1 protein

1

1

High-throughput

0.489

High

948568

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.489

High

1092797

MALL
MAL-like protein

1

2

High-throughput

0.489

High

1093764

GAGE5
G antigen 5

1

2

High-throughput

0.489

High

1365105

ANR50
Ankyrin repeat domain-containing protein 50

1

2

High-throughput

0.489

High

401225

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

404280

GCR
Glucocorticoid receptor

1

12

High-throughput

0.479

High

406447

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

487591

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

520235

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

521839

H14
Histone H1.4

1

2

High-throughput

0.479

High

558298

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

589294

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

621696

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

5

High-throughput

0.479

High

656206

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.479

High

697202

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

714305

PML
Protein PML

1

5

High-throughput

0.479

High

730802

1433S
14-3-3 protein sigma

1

5

High-throughput

0.479

High

831149

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

854899

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

862333

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

980067

H4
Histone H4

1

4

High-throughput

0.479

High

986603

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1113874

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1129669

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

High-throughput

0.479

High

1146750

PCBP1
Poly(rC)-binding protein 1

1

3

High-throughput

0.479

High

1235662

NIPBL
Nipped-B-like protein

1

5

High-throughput

0.479

High

1276564

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1313305

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1329776

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1365089

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1365092

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1365095

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

1365097

WWTR1
WW domain-containing transcription regulator protein 1

1

11

High-throughput

0.479

High

1365101

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1365102

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1365104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

215159

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.458

High

766731

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

974626

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

1004908

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1286997

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.458

High

1352665

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1365090

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1365099

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1365108

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

1365109

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

1365110

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1108374

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

High-throughput

0.445

High

1258528

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.445

High

106372

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

191026

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.437

High

318838

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

346132

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.437

High

768779

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

995734

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.437

High

1365098

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1365100

ANLN
Anillin

1

2

High-throughput

0.437

High

1365103

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.437

High

1365106

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

518883

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

611932

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

301141

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.269

Low

914688

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

1235483

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.249

Low

1365093

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025