HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: DNJC7 (Q99615)
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Gene: DNAJC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	33957083, 18620420, 35271311, 20661446
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006457 - protein folding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 494
+	Hs
		320902 HS74L_HUMAN (1-840): 0: 959: 63.21		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		1267736 HS105_HUMAN (1-840): 0: 938: 62.95		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		714208 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJC3_HUMAN (14-289): 8.21e-26: 112: 17.83
+	Hs
		684440 HSP74_HUMAN (1-840): 0: 993: 100.00		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		279281 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		714449 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB4_HUMAN (380-479): 7.53e-18: 86.7: 45.22
+	Hs
		714326 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB3_HUMAN (381-485): 1.24e-16: 78.6: 40.68
+	Hs
		714317 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB8_HUMAN (381-482): 1.21e-15: 78.2: 44.35
+	Hs
		320819 HS74L_HUMAN (1-840): 0: 959: 63.21		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		714418 HSP74_HUMAN (1-840): 0: 993: 100.00		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Hs
		714148 HSP74_HUMAN (1-840): 0: 993: 100.00		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79
+	Hs
		684925 HS105_HUMAN (1-840): 0: 938: 62.95		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		279330 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		1267773 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB4_HUMAN (380-479): 7.53e-18: 86.7: 45.22
+	Hs
		1123860 HS105_HUMAN (1-840): 0: 938: 62.95		Q59E89_HUMAN (380-479): 1.44e-17: 85.9: 45.22
+	Ce
		183700 HSP1_CAEEL (2-603): 0: 811: 31.48		STIP1_CAEEL (24-195): 7.35e-34: 131: 25.70
+	Dm
		1371973 Q9VUC1_DROME (1-840): 0: 821: 42.10		Q9VPN5_DROME (7-171): 3.79e-22: 101: 29.09
+	Ce
		450534 HSP1_CAEEL (2-603): 0: 811: 31.48		Q20774_CAEEL (380-489): 4.77e-21: 95.9: 46.83
+	Sc
		542113 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		CYC8_YEAST (28-406): 2.74e-32: 133: 15.07
+	Hs
		174578 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59