Protein: DSC1
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)

Gene: DSC1
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q08554

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0001533 - cornified envelope
GO:0002040 - sprouting angiogenesis
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

970760

DSG1
Desmoglein-1

3

17

Small-scale

0.840

High

995966

DSG2
Desmoglein-2

1

19

Small-scale

0.724

High

529034

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

High-throughput

0.628

High

996017

PD1L1
Programmed cell death 1 ligand 1

1

12

High-throughput

0.618

High

551681

DESP
Desmoplakin

2

11

Small-scale

0.595

High

542294

PLAK
Junction plakoglobin

2

20

Small-scale

0.586

High

995963

PKP1
Plakophilin-1

2

20

Small-scale

0.586

High

346625

MYC
Myc proto-oncogene protein

3

11

High-throughput

0.585

High

779301

CCNF
Cyclin-F

2

5

High-throughput

0.549

High

433142

LAMB1
Laminin subunit beta-1

1

4

High-throughput

0.536

High

787219

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.536

High

995968

TNIP1
TNFAIP3-interacting protein 1

2

9

High-throughput

0.533

High

995988

SLX4
Structure-specific endonuclease subunit SLX4

2

4

High-throughput

0.521

High

995969

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

995980

SO4C1
Solute carrier organic anion transporter family member 4C1

1

0

High-throughput

0.513

High

995972

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.500

High

232668

TBCD4
TBC1 domain family member 4

1

4

High-throughput

0.489

High

861717

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.489

High

995960

MK07
Mitogen-activated protein kinase 7

1

5

High-throughput

0.489

High

995973

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

995982

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

High-throughput

0.489

High

995986

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

995993

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

7

High-throughput

0.489

High

995994

GRK7
Rhodopsin kinase GRK7

1

3

High-throughput

0.489

High

995996

ZDH19
Palmitoyltransferase ZDHHC19

1

6

High-throughput

0.489

High

996012

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.489

High

996005

PKP2
Plakophilin-2

1

20

Small-scale

0.481

High

996022

PKP3
Plakophilin-3

1

20

Small-scale

0.481

High

133999

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

309578

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

374113

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

384720

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

427536

ANXA2
Annexin A2

1

6

High-throughput

0.479

High

431214

CATB
Cathepsin B

1

3

Small-scale

0.479

High

503967

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

629114

ZA2G
Zinc-alpha-2-glycoprotein

1

4

High-throughput

0.479

High

683071

CASPE
Caspase-14

1

2

High-throughput

0.479

High

708615

MCM5
DNA replication licensing factor MCM5

1

2

High-throughput

0.479

High

719463

MERL
Merlin

1

18

High-throughput

0.479

High

802579

CRK
Adapter molecule crk

1

13

High-throughput

0.479

High

926968

1433Z
14-3-3 protein zeta/delta

1

18

Small-scale

0.479

High

980245

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.479

High

993940

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.479

High

995958

NFX1
Transcriptional repressor NF-X1

1

5

High-throughput

0.479

High

995965

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

995974

FILA2
Filaggrin-2

1

3

High-throughput

0.479

High

995998

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

996001

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

996004

RANB9
Ran-binding protein 9

1

8

Small-scale

0.479

High

996007

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

9

High-throughput

0.479

High

996009

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

996010

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.479

High

996011

PRD14
PR domain zinc finger protein 14

1

1

Small-scale

0.479

High

996013

S10AE
Protein S100-A14

1

3

High-throughput

0.479

High

996014

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

996015

ANLN
Anillin

1

4

High-throughput

0.479

High

996019

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

996021

FND3A
Fibronectin type-III domain-containing protein 3A

1

20

High-throughput

0.479

High

296296

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

High-throughput

0.470

High

964912

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

995967

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

995970

CDSN
Corneodesmosin

1

0

High-throughput

0.458

High

995975

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.458

High

995978

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

996002

SPB12
Serpin B12

1

0

High-throughput

0.458

High

996003

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

996025

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.457

High

120902

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

882262

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.445

High

887825

CD81
CD81 antigen

1

3

High-throughput

0.445

High

995976

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

282636

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.437

High

379329

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

386609

P53
Cellular tumor antigen p53

1

3

High-throughput

0.437

High

614018

TBG1
Tubulin gamma-1 chain

1

4

High-throughput

0.437

High

625391

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.437

High

832404

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.437

High

851316

NEK2
Serine/threonine-protein kinase Nek2

1

8

Small-scale

0.437

High

902889

DCAF7
DDB1- and CUL4-associated factor 7

1

2

High-throughput

0.437

High

908441

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

940822

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

961071

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

969644

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.437

High

979289

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.437

High

980680

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.437

High

995957

CDC20
Cell division cycle protein 20 homolog

1

3

High-throughput

0.437

High

995961

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

995962

CUL4A
Cullin-4A

1

4

High-throughput

0.437

High

995964

DX39B
Spliceosome RNA helicase DDX39B

1

5

High-throughput

0.437

High

995971

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.437

High

995981

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

995983

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.437

High

995984

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.437

High

995985

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.437

High

995990

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.437

High

995991

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.437

High

995997

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.437

High

995999

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.437

High

996000

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

3

Small-scale

0.437

High

996008

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

996016

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.437

High

996018

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

853868

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.407

High

995989

POC5
Centrosomal protein POC5

1

2

Small-scale

0.407

High

452749

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

996006

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.279

Low

396229

ARGI1
Arginase-1

1

0

High-throughput

0.249

Low

651044

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

995959

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.249

Low

995977

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

995979

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

995987

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.249

Low

995992

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.249

Low

995995

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.249

Low

996020

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

996023

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.249

Low

996024

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1024

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

995956

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024