HitPredict

Interactor 1: GRK5 (P34947)
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
Gene: GRK5

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22952844
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~Pkinase, MMS1_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0006915 - apoptotic process GO:0016055 - Wnt signaling pathway GO:0043066 - negative regulation of apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 590 Hs			1 1140
+	Hs
		794389 GRK6_HUMAN (1-558): 0: 525: 72.27		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		609673 KAPCG_HUMAN (145-500): 1.85e-140: 413: 27.25		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082440 KS6B2_HUMAN (179-501): 6.45e-128: 385: 36.97		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Dm
		1213442 AKT1_DROME (179-518): 6.7e-141: 423: 35.38		DDB1_DROME (1-1140): 0: 1237: 60.84
+	Dm
		1213429 AKT1_DROME (179-518): 6.7e-141: 423: 35.38		SF3B3_DROME (3-1126): 0: 1123: 20.68
+	Dm
		699475 GPRK2_DROME (1-178): 9.64e-30: 126: 38.12		DDB1_DROME (1-1140): 0: 1237: 60.84
+	Dm
		1213363 AKT1_DROME (179-518): 6.7e-141: 423: 35.38		Q8T9L6_DROME (517-1126): 0: 610: 19.28