HitPredict

Interactor 1: CRFR1 (P34998)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: CRHR1

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10598591
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_2~G-alpha
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 354
+	Hs
		391340 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		450978 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		714727 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		926674 PTH1R_HUMAN (41-411): 1.43e-98: 307: 29.66		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		714729 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		686272 VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		793723 GLP1R_HUMAN (2-413): 1.37e-95: 295: 27.52		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		686282 VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		677567 CALCR_HUMAN (37-397): 3.04e-90: 282: 30.00		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23