Protein: PAI2
Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)

Gene: PAI2, SERPINB2
Organism: Homo sapiens
Interactions: 114
UniProt ID: P05120

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366514

TPA
Tissue-type plasminogen activator

2

20

High-throughput

0.811

High

366457

UROK
Urokinase-type plasminogen activator

2

20

Small-scale

0.799

High

424527

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.691

High

424561

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.691

High

424485

CAH8
Carbonic anhydrase-related protein

3

1

High-throughput

0.667

High

171153

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

3

High-throughput

0.628

High

424477

YES
Tyrosine-protein kinase Yes

2

1

High-throughput

0.628

High

424487

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

7

High-throughput

0.628

High

424489

GDF5
Growth/differentiation factor 5

2

8

High-throughput

0.628

High

424498

VIGLN
Vigilin

2

4

High-throughput

0.628

High

424501

FAK1
Focal adhesion kinase 1

2

7

High-throughput

0.628

High

424524

SPICE
Spindle and centriole-associated protein 1

2

1

High-throughput

0.628

High

424525

CCYL1
Cyclin-Y-like protein 1

2

2

High-throughput

0.628

High

424532

IFT81
Intraflagellar transport protein 81 homolog

2

2

High-throughput

0.628

High

424533

LPP
Lipoma-preferred partner

2

2

High-throughput

0.628

High

424539

RSPRY
RING finger and SPRY domain-containing protein 1

2

5

High-throughput

0.628

High

424552

KLC2
Kinesin light chain 2

2

1

High-throughput

0.628

High

424558

RHG35
Rho GTPase-activating protein 35

2

1

High-throughput

0.628

High

424476

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.624

High

424506

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

2

6

High-throughput

0.611

High

424565

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.611

High

424493

CF298
Cilia- and flagella-associated protein 298

3

3

High-throughput

0.609

High

424548

RBM24
RNA-binding protein 24

3

3

High-throughput

0.609

High

273472

DJC13
DnaJ homolog subfamily C member 13

2

0

High-throughput

0.602

High

424483

OSBP1
Oxysterol-binding protein 1

2

0

High-throughput

0.602

High

424503

LIPA1
Liprin-alpha-1

2

0

High-throughput

0.602

High

424509

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

0

High-throughput

0.602

High

424530

RPGF6
Rap guanine nucleotide exchange factor 6

2

0

High-throughput

0.602

High

424535

SYAP1
Synapse-associated protein 1

2

0

High-throughput

0.602

High

424551

ASPC1
Tether containing UBX domain for GLUT4

2

0

High-throughput

0.602

High

424482

PSB1
Proteasome subunit beta type-1

2

1

Small-scale

0.584

High

261358

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

4

High-throughput

0.574

High

284917

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

2

5

High-throughput

0.574

High

424507

EEA1
Early endosome antigen 1

2

3

High-throughput

0.574

High

424516

KDM3B
Lysine-specific demethylase 3B

2

2

High-throughput

0.574

High

424559

GPT2L
G patch domain-containing protein 2-like

2

1

High-throughput

0.574

High

424569

FCF1
rRNA-processing protein FCF1 homolog

2

3

High-throughput

0.574

High

358053

ADH1G
Alcohol dehydrogenase 1C

1

2

High-throughput

0.536

High

424481

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

424484

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

424491

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

424492

SIK1
Serine/threonine-protein kinase SIK1

1

1

High-throughput

0.536

High

424496

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.536

High

424504

GOGA4
Golgin subfamily A member 4

1

2

High-throughput

0.536

High

424518

KHDC4
KH homology domain-containing protein 4

1

3

High-throughput

0.536

High

424523

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.536

High

424545

MMTA2
Multiple myeloma tumor-associated protein 2

1

5

High-throughput

0.536

High

424549

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.536

High

424550

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.536

High

424568

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.536

High

424570

CHMP3
Charged multivesicular body protein 3

1

1

High-throughput

0.536

High

424571

RN115
E3 ubiquitin-protein ligase RNF115

1

7

High-throughput

0.536

High

66918

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

424480

VAV
Proto-oncogene vav

1

0

High-throughput

0.513

High

424555

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.513

High

424514

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

Small-scale

0.504

High

421288

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

424494

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

219796

CHSTA
Carbohydrate sulfotransferase 10

1

3

High-throughput

0.489

High

229203

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.489

High

252502

SEP15
Selenoprotein F

1

3

High-throughput

0.489

High

325262

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

424478

ADT3
ADP/ATP translocase 3

1

7

High-throughput

0.489

High

424486

NU214
Nuclear pore complex protein Nup214

1

1

High-throughput

0.489

High

424495

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

4

High-throughput

0.489

High

424497

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.489

High

424508

TAF5
Transcription initiation factor TFIID subunit 5

1

5

High-throughput

0.489

High

424510

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

424517

NUP54
Nucleoporin p54

1

1

High-throughput

0.489

High

424519

ZC3C1
Zinc finger C3HC-type protein 1

1

4

High-throughput

0.489

High

424522

MICU3
Calcium uptake protein 3, mitochondrial

1

5

High-throughput

0.489

High

424531

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

424534

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.489

High

424537

SARAF
Store-operated calcium entry-associated regulatory factor

1

8

High-throughput

0.489

High

424538

ERP27
Endoplasmic reticulum resident protein 27

1

4

High-throughput

0.489

High

424542

IFT74
Intraflagellar transport protein 74 homolog

1

2

High-throughput

0.489

High

424543

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.489

High

424554

S2532
Solute carrier family 25 member 32

1

10

High-throughput

0.489

High

424564

PHF11
PHD finger protein 11

1

9

High-throughput

0.489

High

424566

PHF8
Histone lysine demethylase PHF8

1

2

High-throughput

0.489

High

424490

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

424505

CUL3
Cullin-3

1

6

High-throughput

0.479

High

345250

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

261059

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.445

High

424479

BMP4
Bone morphogenetic protein 4

1

8

High-throughput

0.445

High

424488

PI4KA
Phosphatidylinositol 4-kinase alpha

1

8

High-throughput

0.445

High

424499

COAA1

1

4

High-throughput

0.445

High

424515

OLFM4
Olfactomedin-4

1

3

High-throughput

0.445

High

424544

PKP2
Plakophilin-2

1

6

High-throughput

0.445

High

424553

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

424572

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

4

High-throughput

0.445

High

417886

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

424502

RBL2
Retinoblastoma-like protein 2

1

1

Small-scale

0.437

High

424511

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

8

High-throughput

0.437

High

424512

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

424528

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.426

High

424536

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.426

High

424526

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

8

High-throughput

0.407

High

424529

IN80E
INO80 complex subunit E

1

1

High-throughput

0.407

High

424546

RSRP1
Arginine/serine-rich protein 1

1

4

High-throughput

0.407

High

424560

CLDN1
Claudin domain-containing protein 1

1

2

High-throughput

0.407

High

424562

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

3

High-throughput

0.407

High

424563

TCAL9
Transcription elongation factor A protein-like 9

1

1

High-throughput

0.407

High

424540

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

424513

FKB15
FK506-binding protein 15

2

0

High-throughput

0.328

High

424520

IT70A
Intraflagellar transport protein 70A

2

0

High-throughput

0.328

High

424521

RLGPB
Ral GTPase-activating protein subunit beta

2

0

High-throughput

0.328

High

424547

SELO
Protein adenylyltransferase SelO, mitochondrial

2

0

High-throughput

0.328

High

424567

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.328

High

424500

UBE3A
Ubiquitin-protein ligase E3A

1

0

Small-scale

0.299

High

424541

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

424557

NJMU
Protein Njmu-R1

1

0

High-throughput

0.279

Low

224879

BUD23
18S rRNA

1

0

High-throughput

0.232

Low

424556

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025