HitPredict

Interactor 1: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	16169070, 35271311
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Actin~Profilin
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome GO:0098685 - Schaffer collateral - CA1 synapse
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 375
+	Hs
		714971 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		891642 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		714946 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Mm
		892215 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		ACTB_MOUSE (1-375): 0: 604: 98.93
+	Bt
		361199 PROF1_BOVIN (1-140): 1.62e-74: 219: 62.14		ACTB_BOVIN (1-375): 0: 604: 98.93
+	Hs
		430115 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		430128 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Mm
		892155 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		ACTB_MOUSE (1-375): 0: 604: 98.93
+	Hs
		714954 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		714951 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTA_HUMAN (2-375): 0: 594: 94.39
+	Hs
		430130 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Bt
		361200 PROF1_BOVIN (1-140): 1.62e-74: 219: 62.14		ACTS_BOVIN (2-375): 0: 594: 93.85
+	Hs
		430125 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTA_HUMAN (2-375): 0: 594: 94.39
+	Hs
		891639 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		891641 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		891640 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTA_HUMAN (2-375): 0: 594: 94.39