Protein: EF1B
Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha)

Gene: EF1B, EEF1B2
Organism: Homo sapiens
Interactions: 201
UniProt ID: P24534

Gene Ontology (top 5):
GO:0003746 - translation elongation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005853 - eukaryotic translation elongation factor 1 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

665382

EF1D
Elongation factor 1-delta

8

3

High-throughput

0.964

High

665415

EF1A1
Elongation factor 1-alpha 1

6

5

High-throughput

0.943

High

665421

EF1A2
Elongation factor 1-alpha 2

5

5

High-throughput

0.922

High

665380

EF1G
Elongation factor 1-gamma

13

17

High-throughput

0.762

High

665376

EF1B
Elongation factor 1-beta

2

3

Small-scale

0.737

High

665395

HD
Huntingtin

2

1

High-throughput

0.621

High

665438

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.618

High

665430

CUL3
Cullin-3

2

8

High-throughput

0.611

High

619498

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.601

High

507538

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

1

Small-scale

0.584

High

665393

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

665422

EP300
Histone acetyltransferase p300

2

2

High-throughput

0.584

High

665499

ANLN
Anillin

2

1

High-throughput

0.584

High

665408

AF17
Protein AF-17

2

4

High-throughput

0.574

High

395508

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

439954

LCK
Tyrosine-protein kinase Lck

2

1

High-throughput

0.571

High

665407

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.571

High

665432

PTK6
Protein-tyrosine kinase 6

2

1

High-throughput

0.571

High

551689

HARS1
Histidine--tRNA ligase, cytoplasmic

1

1

Small-scale

0.561

High

665471

SPRY4
SPRY domain-containing protein 4

2

1

High-throughput

0.553

High

567260

TCTP
Translationally-controlled tumor protein

1

4

Small-scale

0.550

High

665416

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.550

High

135500

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

166121

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

361116

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

529103

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

563215

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

572780

NCF1
Neutrophil cytosol factor 1

1

1

High-throughput

0.536

High

665384

COR1A
Coronin-1A

1

7

High-throughput

0.536

High

665385

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.536

High

665387

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.536

High

665405

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

665428

CUL1
Cullin-1

1

8

High-throughput

0.536

High

665429

CUL2
Cullin-2

1

8

High-throughput

0.536

High

665443

BOREA
Borealin

1

1

High-throughput

0.536

High

665456

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

665476

CUL5
Cullin-5

1

8

High-throughput

0.536

High

665487

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

665500

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

10

High-throughput

0.536

High

316752

MTA2
Metastasis-associated protein MTA2

2

1

High-throughput

0.521

High

665391

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

665397

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

665466

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

421523

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

665392

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.501

High

665475

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

389037

FINC
Fibronectin

1

1

High-throughput

0.489

High

484384

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

617127

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

12

High-throughput

0.489

High

665401

CEBPD
CCAAT/enhancer-binding protein delta

1

9

High-throughput

0.489

High

665482

ERP27
Endoplasmic reticulum resident protein 27

1

3

High-throughput

0.489

High

665494

KDM4C
Lysine-specific demethylase 4C

1

3

High-throughput

0.489

High

665479

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.480

High

125243

LEG9
Galectin-9

1

1

High-throughput

0.479

High

156968

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

277892

SH3L1
Adapter SH3BGRL

1

1

Small-scale

0.479

High

285083

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

293215

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

302379

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

315130

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

324541

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

335002

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

349802

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

375183

RASK
GTPase KRas

1

1

High-throughput

0.479

High

446657

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

534650

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

536523

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

606239

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

659354

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

665377

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

665378

HMGB2
High mobility group protein B2

1

2

High-throughput

0.479

High

665386

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

1

High-throughput

0.479

High

665388

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

665390

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

665396

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

665402

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

665403

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

665406

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

665410

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

665412

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

665414

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

665417

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

665419

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

665420

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.479

High

665423

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

665427

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

665431

DX39B
Spliceosome RNA helicase DDX39B

1

1

Small-scale

0.479

High

665433

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

665434

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.479

High

665436

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

665437

CUL7
Cullin-7

1

1

High-throughput

0.479

High

665441

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

665442

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

665445

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

665446

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

665449

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

665452

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

665453

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.479

High

665457

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

665459

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

665461

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

665462

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

665463

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

665464

MNS1
Meiosis-specific nuclear structural protein 1

1

1

High-throughput

0.479

High

665465

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

665468

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

665470

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

665472

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

665477

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

665480

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

665481

OPTN
Optineurin

1

3

High-throughput

0.479

High

665485

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

665486

NECD
Necdin

1

2

High-throughput

0.479

High

665489

ARP6
Actin-related protein 6

1

1

High-throughput

0.479

High

665491

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

7

Small-scale

0.479

High

665496

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

665498

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

665501

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

665502

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

665505

HDAC6
Protein deacetylase HDAC6

1

2

Small-scale

0.479

High

665506

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

665509

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

665510

FAF1
FAS-associated factor 1

1

1

High-throughput

0.479

High

665513

TLN1
Talin-1

1

2

High-throughput

0.479

High

257342

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

319407

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

362787

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

376711

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

378832

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

538875

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

651154

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

665398

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

665413

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

665424

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

665447

SCND3
SCAN domain-containing protein 3

1

0

High-throughput

0.458

High

665454

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

665469

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

665483

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

665493

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

665503

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

Small-scale

0.458

High

665460

ULK2
Serine/threonine-protein kinase ULK2

1

2

High-throughput

0.457

High

184584

MK13
Mitogen-activated protein kinase 13

1

4

Small-scale

0.445

High

327804

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.445

High

400293

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

665379

SYVC
Valine--tRNA ligase

1

4

Small-scale

0.445

High

665409

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

High-throughput

0.445

High

665440

CRY1
Cryptochrome-1

1

1

Small-scale

0.445

High

665444

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

665490

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.445

High

665492

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

665474

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

217845

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

254523

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

259454

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

352974

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

371187

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

377173

SOMA
Somatotropin

1

1

High-throughput

0.437

High

379877

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

411374

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

458282

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.437

High

473792

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

505474

RBY1D
RNA-binding motif protein, Y chromosome, family 1 member D

1

1

High-throughput

0.437

High

565153

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

587940

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

665381

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

665389

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

665399

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

665404

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.437

High

665411

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

665425

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

665426

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

665435

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

665439

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.437

High

665450

ASXL2
Putative Polycomb group protein ASXL2

1

4

High-throughput

0.437

High

665451

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

665458

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

665467

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

665473

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

665478

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.437

High

665484

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

3

High-throughput

0.437

High

665488

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

665507

BAZ1B
Tyrosine-protein kinase BAZ1B

1

5

High-throughput

0.437

High

665508

F184B
Protein FAM184B

1

2

High-throughput

0.437

High

665511

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.437

High

665512

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

665418

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

429320

JUN
Transcription factor Jun

1

6

High-throughput

0.407

High

665394

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

665400

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.373

High

370005

TIMP1
Metalloproteinase inhibitor 1

1

0

High-throughput

0.282

High

591481

H2AX
Histone H2AX

1

0

High-throughput

0.279

Low

665383

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

596850

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.249

Low

665455

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

665495

HES4
Transcription factor HES-4

1

0

High-throughput

0.249

Low

665497

RTN4
Reticulon-4

1

0

High-throughput

0.249

Low

665504

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

923

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

87335

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

665448

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025